Pentoxifylline suppresses allergic patch test reactions in humans

Use of pentoxifylline in the treatment of allergic contact reactions to plants of the Commelinceae family in dogs

“…9 In one study pentoxifylline successfully suppressed positive patch-test reactions in human patients with con-®rmed contact allergy. 10 Pentoxifylline has been used in human medicine for many years for the symptomatic treatment of various vascular disorders with impaired red blood cell deformability, including peripheral vascular disease, intermittent claudication, ischaemic leg ulcers, diabetes, uraemia, cerebrovascular disease and hypercoagulable states. 6 Pentoxifylline increases red blood cell deformability and decreases blood viscosity by in-hibition of platelet aggregation.…”

“…9 Limited trials have shown that pentoxifylline has been successful in suppressing patch-test reactions in humans with con®rmed contact allergies. 10 Pentoxifylline represents a hopeful new therapy for the management of contact reactions in humans.…”

Pentoxifylline and tumour necrosis factor-induced lung injury

“…Recently, TNF has been identified as a critical mediator in hapteninduced irritant and contact sensitivity reactions [29], thus offering new possibilities, for therapeutic intervention. Meanwhile, the suppressive effect of oral administration of POF on allergic patch test reactions was confirmed in human volunteers known to be allergic to nickel [30].…”

A Randomized, Double-blind, Placebo-Controlled Trial of Pentoxifylline for the Treatment of Recurrent Aphthous Stomatitis

“…However, it has many other potential uses. 28,29 It has been shown to inhibit irritant and contact hypersensitivity, 30,31 and has been used in the treatment of rheumatoid arthritis, multiple sclerosis, and other immunemediated conditions. [32][33][34][35][36][37] Although its mode of action in these conditions is incompletely understood, it seems to possess important immunomodulatory properties.…”