Pentoxifylline attenuates LPS‐induced bronchial hyperresponsiveness but not the increase in exhaled nitric oxide

Abstract

PTX attenuates both the decrease in airway patency and the increase in bronchial responsiveness induced by LPS inhalation, without any significant change in exhaled NO, which is increased by LPS inhalation.

Repeated exposure to organic material alters inflammatory and physiological airway responses

“…Exhaled nitric oxide was unaffected after LPS exposure in all three groups. This is in conflict with earlier findings of elevated exhaled nitric oxide following LPS exposure in a study similar to ours [33]. Exposure in the pig barn induced increased exhaled nitric oxide levels in controls and smokers, but not in farmers.…”

Systemic and bronchial inflammation following LPS inhalation in asthmatic and healthy subjects

“…The response pattern of our study subjects was also different from subjects with stable BHR, who demonstrated a 3-fold increase of eNO over 6 h following LPS inhalation. 18 Our diverse observations might be related to different levels of LBP in asthmatic versus non-asthmatic subjects, especially in our sensitive asthmatics following LPS inhalation. LBP and soluble CD14 levels were markedly elevated in another study in broncho-alveolar lavage fluids obtained from asthmatic subjects after allergen challenge compared to those in normal controls.…”

“…17 A 3-fold significant increase of eNO over 6 h following an inhalation of 60 µg of purified LPS had been seen in eight subjects with stable BHR administered endotoxin. 18 Five of these subjects reported chest tightness and cough after the LPS inhalation. In contrast, Sundblad et al 19 did not find a comparable increase of eNO in healthy volunteers working in a swine house.…”