PLoS ONE volume 9, issue 5, Pe98281 2014 DOI: 10.1371/journal.pone.0098281 View full text
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Ahmad Azhar, Hany M. El-Bassossy

Abstract: We have previously shown that pentoxifylline (PTX) protects from vascular complications associated with insulin resistance (IR). Here, we investigated the protective effect of PTX against cardiac ischemia and dysfunction following experimental angina in IR. IR, along with its accompanying cardiac dysfunction, was induced in rats by a high-fructose (10% in drinking water) high-fat diet for 12 weeks. PTX was administered daily (30 mg⋅kg−1) during the last 4 weeks of the study. Experimental angina was induced by …

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