Penochalasin K, a new unusual chaetoglobosin from the mangrove endophytic fungus Penicillium chrysogenum V11 and its effective semi-synthesis

Zhu, Xinwei; Zhou, Danli; Liang, Fengyan; Wu, Zhihui; She, Zhigang; Li, Chunyuan

doi:10.1016/j.fitote.2017.09.016

Cited by 64 publications

(39 citation statements)

References 26 publications

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“…Studies revealed that chaetoglobosins exhibited significant antibacterial activity against agricultural germs. Zhu et al demonstrated that compound 17 is isolated from the solid culture of the mangrove endophytic fungus.Penicillium chrysogenum V11, possessed significantly antibacterial against Colletotrichum gloeosporioides with the IC 50 value of 6.13 μmol/L [49]. Except for inhibition against agricultural germs, it also showed the effective on clinical pathogenic bacteria.…”

Section: Antibacterial Effectmentioning

confidence: 99%

Bioactivities and Future Perspectives of Chaetoglobosins

Chen

Zhang

Guo

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Chaetoglobosins belonging to cytochalasan alkaloids represent a large class of fungal secondary metabolites. To date, around 100 chaetoglobosins and their analogues have been isolated and identified over the years from a variety of fungi, mainly from the fungus Chaetomium globosum. Studies have found that chaetoglobosins possess a broad range of biological activities, including antitumor, antifungal, phytotoxic, fibrinolytic, antibacterial, nematicidal, anti-inflammatory, and anti-HIV activities. This review will comprehensively summarize the biological activities and mechanisms of action of nature-derived chaetoglobosins.

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Section: Antibacterial Effectmentioning

confidence: 99%

Bioactivities and Future Perspectives of Chaetoglobosins

Chen

Zhang

Guo

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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“…Penochalasin K (13) was discovered by Zhu et al (2017) [21] in the mangrove-associated fungus Penicillium chrysogenum in China. It turned out to be an effective fungicidal compound against C. gloeosporioides and Rhizoctonia solani with ten-fold and two-fold higher activities than the positive control carbendazim, respectively.…”

Section: True Indolesmentioning

confidence: 99%

“…Liu et al [29] recently (2019) detected a new antimicrobial quinazoline in Aspergillus sydowii SW9, living in China's seawater. They named the compound 2-(4-hydroxybenzyl)-4-(3-acetyl)quinazolin- Oxysporizoline (21) was discovered by Nenkep et al (2016) [27] in the marine fungus F. oxysporum in Suncheon Bay, Korea. In an antimicrobial assay, it showed weak antibacterial activity against the Gram + , clinically relevant MRSA and multidrug-resistant S. aureus (MDRSA).…”

Section: Quinazolinesmentioning

confidence: 99%

Alkaloids from Marine Fungi: Promising Antimicrobials

et al. 2020

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Resistance of pathogenic microorganisms against antimicrobials is a major threat to contemporary human society. It necessitates a perpetual influx of novel antimicrobial compounds. More specifically, Gram− pathogens emerged as the most exigent danger. In our continuing quest to search for novel antimicrobial molecules, alkaloids from marine fungi show great promise. However, current reports of such newly discovered alkaloids are often limited to cytotoxicity studies and, moreover, neglect to discuss the enigma of their biosynthesis. Yet, the latter is often a prerequisite to make them available through sufficiently efficient processes. This review aims to summarize novel alkaloids with promising antimicrobial properties discovered in the past five years and produced by marine fungi. Several discovery strategies are summarized, and knowledge gaps in biochemical production routes are identified. Finally, links between the structure of the newly discovered molecules and their activity are proposed. Since 2015, a total of 35 new antimicrobial alkaloids from marine fungi were identified, of which 22 showed an antibacterial activity against Gram− microorganisms. Eight of them can be classified as narrow-spectrum Gram− antibiotics. Despite this promising ratio of novel alkaloids active against Gram− microorganisms, the number of newly discovered antimicrobial alkaloids is low, due to the narrow spectrum of discovery protocols that are used and the fact that antimicrobial properties of newly discovered alkaloids are barely characterized. Alternatives are proposed in this review. In conclusion, this review summarizes novel findings on antimicrobial alkaloids from marine fungi, shows their potential as promising therapeutic candidates, and hints on how to further improve this potential.

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“…Its structure was elucidated by 1D, 2D NMR spectroscopic analysis and high resolution mass spectroscopic data. Compound 111 showed strong cytotoxicity against the MDA-MB-435, SGC-7901 and A549 cell lines with an IC 50 less than 10 µM [ 62 ].…”

Section: Bioactive Compounds In Mangrove Plantsmentioning

confidence: 99%

Mangrove-Associated Fungi: A Novel Source of Potential Anticancer Compounds

Deshmukh

Gupta

Prakash

et al. 2018

JoF

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Cancer is the second leading cause of death worldwide, and the number of cases is increasing alarmingly every year. Current research focuses on the development of novel chemotherapeutic drugs derived from natural as well as synthetic sources. The abundance and diversity in natural resources offer tremendous potential for the discovery of novel molecules with unique mechanisms for cancer therapy. Mangrove-derived fungi are rich source of novel metabolites, comprising novel structure classes with diverse biological activities. Across the globe, coastal areas are primarily dominated by mangrove forests, which offer an intensely complex environment and species that mostly remain unexplored. In recent years, many structurally diverse compounds with unique skeletons have been identified from mangrove fungi and evaluated for their antiproliferative properties. These compounds may serve as lead molecules for the development of new anticancer drugs. Mangrove endophytes can be modulated using epigenetic means or culture optimization methods to improve the yield or to produce various similar analogs. The present review provides an insight into the bioactive metabolites from mangrove endophytes reported during the period from 2012 to 2018 (up to April, 2018) along with their cytotoxic properties, focusing on their chemical structures and mode of action, as indicated in the literature.

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Penochalasin K, a new unusual chaetoglobosin from the mangrove endophytic fungus Penicillium chrysogenum V11 and its effective semi-synthesis

Cited by 64 publications

References 26 publications

Bioactivities and Future Perspectives of Chaetoglobosins

Bioactivities and Future Perspectives of Chaetoglobosins

Alkaloids from Marine Fungi: Promising Antimicrobials

Mangrove-Associated Fungi: A Novel Source of Potential Anticancer Compounds

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