Penile carcinoma and HPV infection (Review)

Iorga, Lucian; Marcu, Radu Dragos; Diaconu, Camelia Cristina; Stănescu, Ana Maria Alexandra; Stoian, Anca Pantea; Mischianu, Dan; Surcel, Mihaela; Bungău, Simona; Constantin, Traian; Boda, Daniel; Fekete, László; Bratu, Ovidiu Gabriel

doi:10.3892/etm.2019.8181

Cited by 34 publications

(42 citation statements)

References 63 publications

(70 reference statements)

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“…The incidence of anogenital warts is increasing in children as low-risk subtypes can be transmitted non-sexually, via fomites, fingers, mouth, and skin, especially through self-inoculation or from mother to child [2,3]. These lesions are a common result of the body's lack of ability to clear HPV infection, and while they are often asymptomatic can cause irritation, bleeding, and pain [15]. HPV infection (namely HPV-6 and HPV-11) is also responsible for benign forms of respiratory papillomatosis.…”

Section: Benign Conditionsmentioning

confidence: 99%

“…Erythroplasia of Queyrat is derived from the mucosal glans of the foreskinwith the highest risk of malignant transformation-while Bowen's disease or squamous cell carcinoma in situ is derived from the keratinized skin of the shaft [8]. Penile cancer may also be identified by histology of usual type squamous cell carcinoma, papillary, warty/condylomas, basaloid, verrucous, or sarcomatoid [15]. HPV has been identified in 33-48% of penile tumors, with HPV 16 and 18 being the most frequently identified, though variations have been found within different histologic subtypes, with basaloid/warty squamous cell carcinoma types mostly associated with HPV infection [8,15].…”

Section: Penile Cancermentioning

confidence: 99%

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Human Papilloma Virus Vaccination

Rosalik

Tarney

Han

2021

Viruses

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Human papilloma virus (HPV) is the most common sexually transmitted infection worldwide causing a variety of benign and malignant conditions. A significant portion of the global population is infected with HPV, with the virus attributed to causing up to 5% of cancers worldwide. Bivalent, quadrivalent, and nine-valent vaccinations exist to aid in the prevention of these diseases and have been proven to be effective at preventing both benign and malignant disease. While vaccination is readily accessible in more developed countries, barriers exist to worldwide distribution and acceptance of vaccination. Vaccination and screening of HPV infection when used in combination are proven and predicted to decrease HPV related pathology. Improvements in vaccination formulations, for treatment as well as prevention, are actively being sought from a variety of mechanisms. Despite these advancements, and the data supporting their efficacy, there has been substantial delay in obtaining adequate vaccination coverage. In reviewing these challenges and looking forward to new vaccine development—especially within the current pandemic—it is clear from the challenges of HPV we require methods to more effectively encourage vaccination, ways to dispel vaccination myths as they occur, and implement better processes for vaccine distribution globally.

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Section: Benign Conditionsmentioning

confidence: 99%

Section: Penile Cancermentioning

confidence: 99%

Human Papilloma Virus Vaccination

Rosalik

Tarney

Han

2021

Viruses

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“…En los hombres la prevalencia de la infección no declina con la edad [4]. El VPH se detecta entre el 45% al 80% de los pacientes con cáncer de pene, usualmente el VPH16, con una baja incidencia de 22.000 casos anuales a nivel mundial, afectando en su gran mayoría a los hombres con edades entre 50 y 70 años [4,5,[28][29][30].…”

Section: Partículas Virales Infecciosasunclassified

Virus del papiloma humano (VPH) y cáncer

Toro-Montoya

Tapia-Vela²

2021

Med. Lab.

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Cada año, más de medio millón de mujeres en el mundo son diagnosticadas con cáncer cervical, usualmente asociado a la infección por virus del papiloma humano (VPH) de alto riesgo. Aunque la mayoría de las infecciones por VPH se resuelven dentro de un término menor de 2 años, algunos tipos virales, en particular el VPH16, pueden persistir por décadas y originar diferentes tipos de cáncer, siendo el cervical el más común. La historia natural de la infección por VPH de alto riesgo y el periodo prolongado en que ocurre su progresión, permite la prevención de la enfermedad. La infección por VPH de alto riesgo que evoluciona a cáncer incluye varios procesos como la integración del genoma viral, la división celular incontrolada, y la participación de cambios celulares y epigenéticos. La prueba de citología convencional que se viene practicando para la tamización hace más de 50 años continúa teniendo vigencia, especialmente en países de ingresos bajos y medios, pero está siendo reemplazada por otros métodos como las pruebas moleculares que detectan directamente la presencia del virus, con mayor efectividad como prueba de tamización. En 2014, el Ministerio de Salud y Protección Social de Colombia desarrolló una guía de práctica clínica para la detección y manejo de lesiones premalignas de cuello uterino, en la cual se recomienda la prueba de ADN-VPH para la tamización inicial en las mujeres mayores de 30 años. Hasta el momento se han encontrado resultados positivos con la implementación de la prueba, no obstante, se requieren estudios adicionales que confirmen estos hallazgos, dada su importancia en el control de la morbilidad y mortalidad asociadas a la infección.

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“…There are no data available in Romania on the skin health of patients with HIV infection or the general population, neither globally nor regionally (southeastern region), except for various cases of malignancies (Kaposi' sarcoma, Paget's disease) reported for patients with HIV or manifestations of human papilloma virus (HPV) infection in the general population (7)(8)(9)(10)(11). Based on these grounds, we conducted this study to investigate the skin health of PLWH in the southeastern part of Romania.…”

Section: Introductionmentioning

confidence: 99%

Perspectives on skin disorder diagnosis among people living with HIV in southeastern Romania

et al. 2020

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The beginnings of the human immunodeficiency virus (HIV) pandemic are closely linked to dermatological conditions. A large part of the population living with HIV (PLWH) has a series of skin conditions that determine at some point, a visit to the dermatologist. The introduction of highly active antiretroviral therapy (HAART) more than 20 years ago has diminished the range of dermatological conditions, with improved immunosuppression of CD4 lymphocytes. The study aimed to describe the prevalence of the diagnosed type of skin changes in PLWH receiving antiretroviral therapy and their stratification according to the degree of immunodeficiency. A prospective study was conducted on 57 PLWH evaluated monthly at an HIV outpatient clinic, from a tertiary hospital in southeastern Romania. Clinical examination and dermoscopy revealed the existence of a wide range of dermatological conditions; all 57 patients (100%) being diagnosed with one or more dermatological conditions. As our study shows, the prevalence of different dermatoses among PLWH varies depending on the geographical region. At the same time, under HAART, the image of dermatoses associated with decreased immunity from HIV infection has changed. The skin changes of PLWH no longer fully follow the classical staging, based on the degree of immunosuppression.

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Penile carcinoma and HPV infection (Review)

Cited by 34 publications

References 63 publications

Human Papilloma Virus Vaccination

Human Papilloma Virus Vaccination

Virus del papiloma humano (VPH) y cáncer

Perspectives on skin disorder diagnosis among people living with HIV in southeastern Romania

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