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“…In the late 1980s and early 1990s, reports of therapeutic failures with cephalosporins for meningitis due to CEPH-resistant pneumococci were published. 42,43,180,[210][211][212][213][214][215][216] In light of the escalating b-lactam resistance, by the mid-to late-1990s the combination of vancomycin in addition to cefotaxime or ceftriaxone was considered standard care for pneumococcal meningitis. 189,193,194 However, there is no strong evidence that outcomes are worse among patients with CEPHresistant pneumococci.…”
Section: Clinical Significance Of Cephalosporin Resistancementioning
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“…In the late 1980s and early 1990s, reports of therapeutic failures with cephalosporins for meningitis due to CEPH-resistant pneumococci were published. 42,43,180,[210][211][212][213][214][215][216] In light of the escalating b-lactam resistance, by the mid-to late-1990s the combination of vancomycin in addition to cefotaxime or ceftriaxone was considered standard care for pneumococcal meningitis. 189,193,194 However, there is no strong evidence that outcomes are worse among patients with CEPHresistant pneumococci.…”
Section: Clinical Significance Of Cephalosporin Resistancementioning
“…In the late 1980s and early 1990s, reports of therapeutic failures with cephalosporins for meningitis due to cephalosporin-resistant pneumococci were published. 74,75,85,226,[250][251][252][253][254][255] In light of the escalating b-lactam resistance, the American Academy of Pediatrics recommended vancomycin in addition to cefotaxime or ceftriaxone for treatment of suspected pneumococcal meningitis. 234 This recommendation was also proposed for treating adults with suspected pneumococcal meningitis.…”
Section: Clinical Significance Of Cephalosporin Resistancementioning