Penicillin in the Treatment of Experimental Syphilis of Rabbits

Kolmer, John A.

doi:10.1001/archderm.1950.01530080055005

Search citation statements

Order By: Relevance

Paper Sections

Select...

Discussion1

Citation Types

Supporting

Mentioning

Contrasting

Year Published

1950

1987

Publication Types

Select...

Article5

Book1

Relationship

Self Cite0

Independent6

Authors

Journals

Cited by 7 publications

(1 citation statement)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In difference to the study undertaken by Johnson et al [7] the present investigation was not based on the curative dose for 50% of infected animals, but aimed at the establishment of a treat ment protocol leading to cure in all in fected animals. To us this seems to be helpful with respect to clinical implica tions, the more so as early studies in rab bits, establishing the potency of penicillin in syphilis, were also mainly based on this critérium [4,8].…”

Section: Discussionmentioning

confidence: 99%

Ceftriaxone Given Repeatedly Cures Manifest Syphilis in the Rabbit

Körting

Walther²,

Riethmüller³

et al. 1987

Chemotherapy

View full text Add to dashboard Cite

Repeated intramuscular injection of ceftriaxone to rabbits with manifest syphilitic orchitis leads to clinical cure as does penicillin, given the serum levels reached are similar to the ones obtained clinically in man. Totally different to untreated controls the Treponema pallidum hemagglutination (TPHA) titers remain relatively low and later even tend to decrease further. Thus, it seems justified to start clinical trials on the definite role of ceftriaxone in the treatment of clinical syphilis.

show abstract

Section: Discussionmentioning

confidence: 99%