Penicillin compared with other advanced broad spectrum antibiotics regarding antibacterial activity against oral pathogens isolated from odontogenic abscesses

Warnke, Patrick H.; Becker, Stephan; Springer, Ingo N.; Haerle, Franz; Ullmann, U.; Russo, Paul; Wiltfang, Jens; Fickenscher, Helmut; Schubert, Sabine

doi:10.1016/j.jcms.2008.07.001

Cited by 73 publications

(50 citation statements)

References 21 publications

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“…and Fusobacterium spp., and facultative anaerobes, such as viridans group streptococci, to be the predominant pathogens (1,15,21). Our average number of isolates per specimen, 2.6, is well in line with the range of 1 to 24 reported in the literature (10,18,21).…”

Section: Discussionsupporting

confidence: 89%

“…Often taking a mild course, these infections may also produce life-threatening complications, depending on a patient's immunocompetence and the site of the inflammatory process. These infections are typically polymicrobial, and anaerobic bacteria are thought to play a central etiologic role (1,15,18,21). Antibiotics are an important component in the treatment of odontogenic infections.…”

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confidence: 99%

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Microbiological Analysis of a Prospective, Randomized, Double-Blind Trial Comparing Moxifloxacin and Clindamycin in the Treatment of Odontogenic Infiltrates and Abscesses

Sobottka

Wegscheider

Balzer

et al. 2012

Antimicrob Agents Chemother

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The objective of this study was to identify the oral pathogens found in odontogenic infections, to determine their susceptibilities to amoxicillin-clavulanic acid (AMC), clindamycin (CLI), doxycycline (DOX), levofloxacin (LVX), moxifloxacin (MXF), and penicillin (PEN), and to search for associations between specific pathogens and types of infection. Swabs from patients enrolled in a randomized, double-blind phase II trial comparing MXF with CLI for the treatment of odontogenic abscesses or inflammatory infiltrates were cultured on media for aerobes and anaerobes. All bacterial isolates were identified at the species level. Overall, 205 isolates were cultured from 71 patients: 77 viridans group streptococci, 56 Prevotella spp., 19 Neisseria spp., 17 Streptococcus anginosus group isolates and hemolytic streptococci, 15 other anaerobes, and 21 other bacteria. Ninety-eight percent of pathogens were susceptible to MXF, 96% to AMC, 85% to LVX, 67% to PEN, 60% to CLI, and 50% to DOX. S. anginosus group and hemolytic streptococci were found significantly more frequently (P ‫؍‬ 0.04) in patients with abscesses (12/95) than in patients with infiltrates (5/110). In four patients with infiltrates who failed to respond to CLI therapy, three isolates of the Streptococcus mitis group and four Neisseria spp. resistant to CLI were found. In this study, S. anginosus group and hemolytic streptococci were clearly associated with odontogenic abscesses. Our analysis suggests that viridans group streptococci and Neisseria spp. play a decisive role in the etiology of odontogenic infiltrates. The high in vitro activity of MXF against odontogenic bacteria corresponds well to its clinical results in the treatment of odontogenic abscesses and infiltrates.

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Section: Discussionsupporting

confidence: 89%

mentioning

confidence: 99%

Microbiological Analysis of a Prospective, Randomized, Double-Blind Trial Comparing Moxifloxacin and Clindamycin in the Treatment of Odontogenic Infiltrates and Abscesses

Sobottka

Wegscheider

Balzer

et al. 2012

Antimicrob Agents Chemother

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“…Anaerobic coverage might also be selected if a dental etiology is suspected. 1,4,5,8 In our case, in the culture of the purulent Before the treatment.…”

Section: Discussionmentioning

confidence: 59%

Isolated Idiopathic Lip Abscess: A Case Report

Yılmaz¹,

Güven²,

Cesur³

et al. 2011

Sakarya Med J

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ÖzetHerhangi bir sistemik hastalık veya immun sistem bozukluğu gibi prezdisozan faktör olmaksızın idiyopatik olarak ortaya çıkan izole dudak absesi nadiren görülür. Bu yazıda herhangi bir predispozan faktör olmadan gelişen izole alt dudak absesi olgusu sunularak hastalığın etiyolojisi ve tedavisi tartışıldı. AbstractIsolated lip abscess which is idiopathic and without any predisposing factors such as immune deficiency or systemic disease is seen rarely. We aimed to present a case of lower lip abscess which is isolated and without any predisposing factor and discussed its etiology and treatment.

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“…It explains the reason for higher MICs in gram-ve. Moreover, some compounds like standard drug penicillin G selectively act on a class of bacteria thereby it effectively kills gram+ve bacteria, but not gramve bacteria [12,13].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Antibacterial Efficacy of Digera Muricata Plant using Microbroth Dilution and Autobiography Assays

Malik¹,

Tjprc²

2018

IJBR

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Penicillin compared with other advanced broad spectrum antibiotics regarding antibacterial activity against oral pathogens isolated from odontogenic abscesses

Cited by 73 publications

References 21 publications

Microbiological Analysis of a Prospective, Randomized, Double-Blind Trial Comparing Moxifloxacin and Clindamycin in the Treatment of Odontogenic Infiltrates and Abscesses

Microbiological Analysis of a Prospective, Randomized, Double-Blind Trial Comparing Moxifloxacin and Clindamycin in the Treatment of Odontogenic Infiltrates and Abscesses

Isolated Idiopathic Lip Abscess: A Case Report

Evaluation of Antibacterial Efficacy of Digera Muricata Plant using Microbroth Dilution and Autobiography Assays

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