Penetration of Intact Skin by Quantum Dots with Diverse Physicochemical Properties

Ryman-Rasmussen, Jessica P.; Riviere, Jim E.; Monteiro‐Riviere, Nancy A.

doi:10.1093/toxsci/kfj122

Cited by 453 publications

(274 citation statements)

References 21 publications

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“…It has also been shown that QD are capable of penetrating intact skin [13]. These preliminary studies suggest that extra care should be taken during QD handling especially during their manufacturing, since systemic toxicity can occur via QD inhalation and direct skin contact.…”

Section: Mechanism Of Qd Toxicitymentioning

confidence: 92%

Quantum Dot Toxicity

Al-Jama1¹,

Kostarelos²

2016

Encyclopedia of Nanotechnology

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Section: Mechanism Of Qd Toxicitymentioning

confidence: 92%

Quantum Dot Toxicity

Al-Jama1¹,

Kostarelos²

2016

Encyclopedia of Nanotechnology

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“…Quantum dots were found in the dermis and epidermis [122]. Quantum dots with an anionic coating penetrated much slower than those with cationic or neutral coatings [123].…”

Section: Human Health Hazards Following From Dermal Exposure To Persimentioning

confidence: 99%

“…Ryman-Rasmussen et al [122] found that nano-sized quantum dots with a variety of physicochemical properties might be able to penetrate the stratum corneum of the porcine skin in the absence of abrasion or mechanical stress. Quantum dots were found in the dermis and epidermis [122].…”

Section: Human Health Hazards Following From Dermal Exposure To Persimentioning

confidence: 99%

“…From the studies regarding skin exposure to nanoparticles [7,16,109,[117][118][119][120][121][122][123][124][125][126][127][128][129][130][131][132][133] several likely determinants of hazard emerge. These include size, chemical composition, surface characteristics, such as surface coating and surface charge, and crystalline structure.…”

Section: Human Health Hazards Following From Dermal Exposure To Persimentioning

confidence: 99%

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Human health hazards of persistent inorganic and carbon nanoparticles

Reijnders

2012

J Mater Sci

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Persistent inorganic and carbon nanoparticles are increasingly engineered for applications and may also be present in conventional materials such as carbon black. Furthermore, they may originate from conventional non particulate materials by processes such as wear and tear. Persistent inorganic and carbon nanoparticles can be hazardous to humans. Relatively much research regards the hazards of inhaled nanoparticles. These may give rise to respiratory disease and to negative effects on other organs, including the cardiovascular system. Determinants of risk of inhaled nanoparticles include: number, size, surface characteristics, shape, structure, and the formation of assemblages. These determinants should preferentially be considered in exposure metrics. A major molecular mechanism underlying the inhalation hazard of nanoparticles is the generation of reactive oxygen species, but other mechanisms such as interactions with proteins and DNA may also contribute. Health hazards may also be linked to ingestion of persistent inorganic and carbon nanoparticles, dermal exposure and exposure of the eye. Standards for workplace exposure to persistent inorganic and carbon are currently emerging and there are options for hazard reduction by elimination and substitution of hazardous nanoparticles and by engineering controls.

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“…Tinkle et al [2003] have shown that particles smaller than 1 µm in diameter may penetrate into mechanically flexed skin samples. A more recent study reported that nanoparticles with varying physicochemical properties were able to penetrate the intact skin of pigs [Ryman-Rasmussen et al 2006]. These nanoparticles were quantum dots of different size, shape, and surface coatings.…”

mentioning

confidence: 99%

Approaches to safe nanotechnology: managing the health and safety concerns associated with engineered nanomaterials (withdrawn).

2009

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To receive documents or other information about occupational safety and health topics, contact NIOSH at Telephone: 1-800-CDC-INFO (1-800-232-4636) TTY: 1-888-232-6348 E-mail: cdcinfo@cdc.gov or visit the NIOSH Web site at www.cdc.gov/niosh.For a monthly update on news at NIOSH, subscribe to NIOSH eNews by visiting www.cdc.gov/niosh/eNews. No. 2009-125 March 2009 DHHS (NIOSH) Publication Safer • Healthier • People™Approaches to Safe Nanotechnology iii Nanotechnology-the manipulation of matter on a near-atomic scale to produce new structures, materials, and devices-offers the promise of unprecedented scientific advancement for many sectors, such as medicine, consumer products, energy, materials, and manufacturing. Nanotechnology has the power not only to improve existing technologies, but to dramatically enhance the effectiveness of new applications.Research on the potential applications of nanotechnology continues to expand rapidly worldwide. New nanotechnology consumer products emerge at a rate of three to four per week. Over the course of the next decade, nanotechnology could have a $1 trillion impact on the global economy and employ two million workers-half of them residing in the U.S.While nanomaterials present seemingly limitless possibilities, they bring with them new challenges to understanding, predicting, and managing potential safety and health risks to workers. The National Institute for Occupational Safety and Health (NIOSH) remains committed to protecting workers now and in the future, as nanotechnology applications and uses expand.As part of these efforts, in October 2005, NIOSH released for public comment the draft document, Approaches to Safe Nanotechnology: An Information Exchange with NIOSH. Based on feedback received, NIOSH revised and updated the document in July 2006 and sought further public comment. This draft report has been widely cited, and the final version of the report should serve as a vital resource for stakeholders (including occupational safety and health professionals, researchers, policy makers, risk assessors, and workers in the industry) who wish to understand more about the safety and health implications of nanotechnology in the workplace.With the publication of the Approaches to Safe Nanotechnology document, NIOSH hopes to: raise awareness of the occupational safety and health issues involved with nanotechnology; make recommendations on occupational safety and health best practices in the production and use of nanomaterials; facilitate dialogue between NIOSH and its external partners in industry, labor and academia; respond to requests for authoritative safety and health guidelines; and, identify information gaps and areas for future study and research.As our knowledge of nanoscience increases, so too will our efforts to provide valuable guidance on the safe handling of nanoparticles and for protecting the lives and livelihoods of nanotechnology workers.

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Penetration of Intact Skin by Quantum Dots with Diverse Physicochemical Properties

Cited by 453 publications

References 21 publications

Quantum Dot Toxicity

Quantum Dot Toxicity

Human health hazards of persistent inorganic and carbon nanoparticles

Approaches to safe nanotechnology: managing the health and safety concerns associated with engineered nanomaterials (withdrawn).

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