Penazetidine A, an alkaloid inhibitor of protein kinase C

Alvi, Khisal A.; Jaspars, Marcel; Crews, Phillip; Strulovici, Berta; Oto, Edwin

doi:10.1016/s0960-894x(01)80407-8

Cited by 57 publications

(39 citation statements)

References 16 publications

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“…The molecular formula of asterriquinone SU5501 (6) and most of the spectroscopic properties were very similar to that of5. Just like 5, 6 also had two types ofdimethyl allyl groups (i.e., a 1,1-and a 3,3-dimethyl allyl group).…”

Section: Preparation Of Cell Lysates and Gstfusion Proteinsmentioning

confidence: 64%

Asterriquinones Produced by Aspergillus candidus Inhibit Binding of the Grb-2 Adapter to Phosphorylated EGF Receptor Tyrosine Kinase.

Alvi¹,

Luche

et al. 1999

J. Antibiot.

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Five new asterriquinone analogs (2~4, 6, 7), together with previously identified neoasterriquinone (1) and isoasterriquinone (5), were isolated from a fermentation broth of the fungus Aspergillus candidus and purified by HSCCC(high speed counter current chromatography) followed by HPLC. The structures were determined by ID and 2D NMR and MS/MStechniques. All seven showed inhibitory activity against the binding of a recombinant protein containing the SH2 protein domain of Grb-2 to the tyrosine phosphorylated form of the EGFreceptor tyrosine kinase. Someof these asterriquinones exhibited specific inhibition of Grb-2 binding compared to Grb-7 and PLC-y.In this present study, we sought to identify non-

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Section: Preparation Of Cell Lysates and Gstfusion Proteinsmentioning

confidence: 64%

Asterriquinones Produced by Aspergillus candidus Inhibit Binding of the Grb-2 Adapter to Phosphorylated EGF Receptor Tyrosine Kinase.

Alvi¹,

Luche

et al. 1999

J. Antibiot.

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“…Lasonolide A (isolated from the Caribbean sponge Forcepia sp.) [ 245 ], penazetidine A (isolated from the marine sponge Penares sollasi ) [ 246 ] and corallidictyals A and B (isolated from the marine sponge Aka coralliphaga ) also showed potent inhibitory activity against PKC.…”

Section: Mnps Under Research or In Preclinical Stages Classified Bmentioning

confidence: 99%

An Updated Review on Marine Anticancer Compounds: The Use of Virtual Screening for the Discovery of Small-Molecule Cancer Drugs

et al. 2017

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Marine secondary metabolites are a promising source of unexploited drugs that have a wide structural diversity and have shown a variety of biological activities. These compounds are produced in response to the harsh and competitive conditions that occur in the marine environment. Invertebrates are considered to be among the groups with the richest biodiversity. To date, a significant number of marine natural products (MNPs) have been established as antineoplastic drugs. This review gives an overview of MNPs, both in research or clinical stages, from diverse organisms that were reported as being active or potentially active in cancer treatment in the past seventeen years (from January 2000 until April 2017) and describes their putative mechanisms of action. The structural diversity of MNPs is also highlighted and compared with the small-molecule anticancer drugs in clinical use. In addition, this review examines the use of virtual screening for MNP-based drug discovery and reveals that classical approaches for the selection of drug candidates based on ADMET (absorption, distribution, metabolism, excretion, and toxicity) filtering may miss potential anticancer lead compounds. Finally, we introduce a novel and publically accessible chemical library of MNPs for virtual screening purposes.

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“…Penazetidine A (136) was isolated from the Indo-Pacific marine sponge Penares sollasi [164]. Similarly to penaresidin A (134) and B (135), the chemical structure of penazetidine A (136) contains an interesting azetidine ring structure.…”

Section: Penazetidine Amentioning

confidence: 99%

Sphingolipids in Anticancer Therapy

Padrón

2006

CMC

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Sphingolipids constitute a broad class of compounds with many biological functions. The sphingolipid metabolites ceramide and sphingosine are potent apoptosis inducers and produce cell cycle arrest, whereas sphingosine-1-phosphate promotes cellular growth and differentiation. Herein, the effects of sphingolipids and their analogs on diverse signaling pathways implicated in the apoptotic process are highlighted. The relatively simple chemical structure of these compounds has led to several strategies for their total synthesis. Those methods have contributed to the development and biological study of several analogs that present diverse degree of modification from the original structure. This article catalogues many of the recently developed synthetic analogs that act on diverse aspects of sphingolipid metabolism. A description of known enzyme inhibitors of the sphigolipids pathway is also given. Finally, diverse new sphingolipid-like antitumor agents isolated from marine sources are presented. This contribution opens the way for future development of new sphingolipid analogs that might be useful in cancer chemotherapy.

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Penazetidine A, an alkaloid inhibitor of protein kinase C

Cited by 57 publications

References 16 publications

Asterriquinones Produced by Aspergillus candidus Inhibit Binding of the Grb-2 Adapter to Phosphorylated EGF Receptor Tyrosine Kinase.

Asterriquinones Produced by Aspergillus candidus Inhibit Binding of the Grb-2 Adapter to Phosphorylated EGF Receptor Tyrosine Kinase.

An Updated Review on Marine Anticancer Compounds: The Use of Virtual Screening for the Discovery of Small-Molecule Cancer Drugs

Sphingolipids in Anticancer Therapy

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