Pen-on-paper strategies for point-of-care testing of human health

Li, Zedong; Liu, Hao; He, Xiaocong; Xu, Feng; Li, Fēi

doi:10.1016/j.trac.2018.08.010

Cited by 50 publications

(28 citation statements)

References 107 publications

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“…Garcia et al presented a handheld stamping process that produced a µPAD in seconds independently of the user’s technical skills [ 114 ]. We considered the fabrication methods that involve digitally control (e.g., wax printing, inkjet printing, and digital cutter) provides high reproducibility compared to the manual control methods (e.g., handwriting) [ 18 , 33 , 34 , 36 , 37 , 53 , 54 , 73 , 115 ].…”

Section: Fabrication Of µPadsmentioning

confidence: 99%

Recent Advances in Microfluidic Paper-Based Analytical Devices toward High-Throughput Screening

et al. 2020

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Microfluidic paper-based analytical devices (µPADs) have become promising tools offering various analytical applications for chemical and biological assays at the point-of-care (POC). Compared to traditional microfluidic devices, µPADs offer notable advantages; they are cost-effective, easily fabricated, disposable, and portable. Because of our better understanding and advanced engineering of µPADs, multistep assays, high detection sensitivity, and rapid result readout have become possible, and recently developed µPADs have gained extensive interest in parallel analyses to detect biomarkers of interest. In this review, we focus on recent developments in order to achieve µPADs with high-throughput capability. We discuss existing fabrication techniques and designs, and we introduce and discuss current detection methods and their applications to multiplexed detection assays in relation to clinical diagnosis, drug analysis and screening, environmental monitoring, and food and beverage quality control. A summary with future perspectives for µPADs is also presented.

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Section: Fabrication Of µPadsmentioning

confidence: 99%

Recent Advances in Microfluidic Paper-Based Analytical Devices toward High-Throughput Screening

et al. 2020

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“…As a result of recent advances in the field of PADs, a host of devices have been developed for application in various fields such as clinical diagnostics and point-of-care testing, environmental monitoring and food quality control [9][10][11]. The patterning of the hydrophobic barriers is a critical step in the fabrication of PADs and several approaches have been proposed in the literature; the relative advantages and drawbacks of these methods have been summarized in many relevant reviews [8,[12][13][14][15][16][17]. Among them, penon-paper (PoP) strategies involve the use of a writing tool (i.e., suitable pen, crayon, pencil or marker) to deposit functional materials on paper substrates with the view to create either hydrophobic patterns or conductive areas (electrodes) [15].…”

Section: Introductionmentioning

confidence: 99%

“…The patterning of the hydrophobic barriers is a critical step in the fabrication of PADs and several approaches have been proposed in the literature; the relative advantages and drawbacks of these methods have been summarized in many relevant reviews [8,[12][13][14][15][16][17]. Among them, penon-paper (PoP) strategies involve the use of a writing tool (i.e., suitable pen, crayon, pencil or marker) to deposit functional materials on paper substrates with the view to create either hydrophobic patterns or conductive areas (electrodes) [15]. PoP is considered as a promising do-it-yourself approach towards the fabrication of "one-dollar PADs" [16,18].…”

Section: Introductionmentioning

confidence: 99%

“…Finally, applicability of the fully PoP-drawn PADs was demonstrated for optical and electrochemical detection. Compared to the most popular PAD fabrication methods (wax printing, inkjet printing and lithography), the proposed PoP approach exhibits the following advantages: it does not require pre-or post-fabrication treatment (heating or curing), thereby simplifying and speeding up the manufacturing process; it utilizes lower cost and commercially available writing stationary; it offers greater flexibility since the drawing process can be readily fine-tuned (in terms of single-or double-sided plotting, number of passes and plotting speed); and, more significantly, it enables the fabrication of both fluidic patterns and electrodes with the same equipment in a sequential dual-step mode by merely exchanging writing tools [15,16,18].…”

Section: Introductionmentioning

confidence: 99%

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Development of a High-Throughput Low-Cost Approach for Fabricating Fully Drawn Paper-Based Analytical Devices Using Commercial Writing Tools

et al. 2021

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This work reports the development and optimization of a rapid and low-cost pen-on-paper plotting approach for the fabrication of paper-based analytical devices (PADs) using commercial writing stationery. The desired fluidic patterns were drawn on the paper substrate with commercial marker pens using an inexpensive computer-controlled x–y plotter. For the fabrication of electrochemical PADs, electrodes were further deposited on the devices using a second x–y plotting step with commercial writing pencils. The effect of the fabrication parameters (type of paper, type of marker pen, type of pencil, plotting speed, number of passes, single- vs. double-sided plotting), the chemical resistance of the plotted devices to different solvents and the structural rigidity to multiple loading cycles were assessed. The analytical utility of these devices is demonstrated through application in optical sensing of total phenols using reflectance calorimetry and in electrochemical sensing of paracetamol and ascorbic acid. The proposed manufacturing approach is simple, low cost, flexible, rapid and fit-for-purpose and enables the fabrication of sub-“one-dollar” PADs with satisfactory mechanical and chemical resistance and good analytical performance.

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“…Point-of-care diagnostics (POCD) for health monitoring involves the evaluation of indices from human health through tests performed outside of the clinical laboratory, typically right at the site of patient care [1,2,3,4]. While the advantages of POCD such as rapid diagnosis, operational efficiency, and costs have been well established [2], widespread implementation of this technology has not yet been achieved [5].…”

Section: Introductionmentioning

confidence: 99%

Acoustofluidic Micromixing Enabled Hybrid Integrated Colorimetric Sensing, for Rapid Point-of-Care Measurement of Salivary Potassium

et al. 2019

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The integration of microfluidics with advanced biosensor technologies offers tremendous advantages such as smaller sample volume requirement and precise handling of samples and reagents, for developing affordable point-of-care testing methodologies that could be used in hospitals for monitoring patients. However, the success and popularity of point-of-care diagnosis lies with the generation of instantaneous and reliable results through in situ tests conducted in a painless, non-invasive manner. This work presents the development of a simple, hybrid integrated optical microfluidic biosensor for rapid detection of analytes in test samples. The proposed biosensor works on the principle of colorimetric optical absorption, wherein samples mixed with suitable chromogenic substrates induce a color change dependent upon the analyte concentration that could then be detected by the absorbance of light in its path length. This optical detection scheme has been hybrid integrated with an acoustofluidic micromixing unit to enable uniform mixing of fluids within the device. As a proof-of-concept, we have demonstrated the real-time application of our biosensor format for the detection of potassium in whole saliva samples. The results show that our lab-on-a-chip technology could provide a useful strategy in biomedical diagnoses for rapid analyte detection towards clinical point-of-care testing applications.

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Pen-on-paper strategies for point-of-care testing of human health

Cited by 50 publications

References 107 publications

Recent Advances in Microfluidic Paper-Based Analytical Devices toward High-Throughput Screening

Recent Advances in Microfluidic Paper-Based Analytical Devices toward High-Throughput Screening

Development of a High-Throughput Low-Cost Approach for Fabricating Fully Drawn Paper-Based Analytical Devices Using Commercial Writing Tools

Acoustofluidic Micromixing Enabled Hybrid Integrated Colorimetric Sensing, for Rapid Point-of-Care Measurement of Salivary Potassium

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