Pemphigus Vulgaris with Lesions of the Rectal Mucosa

Anal Involvement in Pemphigus Vulgaris

“…One of these three previously reported patients had widespread involvement at multiple mucosal and cutaneous sites. 8 The patients in the cohort we report also had oral involvement of PV but tended to have more widespread and severe overall disease than the three previously reported patients with anal involvement. In addition, our long-term follow-up (mean of 53 months) indicated that multiple episodes of anal disease are relatively common, with nine patients having recurrent anal disease.…”

“…[8][9][10] These three patients had PV begin in the oral cavity and developed anal lesions at a mean of 15 (range, 2-40) months after disease onset. One of these three previously reported patients had widespread involvement at multiple mucosal and cutaneous sites.…”

“…Anal biopsies were not performed on patients in the earlier reports. [8][9][10] We believe that the resolution of anal disease, without sequelae, can in part be attributed to the focused and detailed attention paid to the management of issues specific to anal disease. The mainstay of the management of anal disease consisted of 1) anal hygiene, 2) topical care, 3) diet, and 4) use of laxatives.…”

A Case of an Atypical Mycobacterial Ulcer Following an Intramuscular

“…Malik et al report a significantly higher incidence of anal involvement in their smaller cohort (10% of 160 PV cases) and propose that this may even be an underestimate due to misdiagnosis or underreporting (7). However, apart from these two studies, only four other cases suggestive of anorectal involvement have been previously documented and none with biopsyproven diagnosis (8)(9)(10)(11). To our knowledge, the case we describe here is one of the first with histopathologic confirmation.…”

Anal Involvement in Pemphigus Vularis

“…The few patients described in the literature also tended to have involvement of PV at multiple sites, especially the oral mucosa. Epstein et al reported a patient with widespread involvement at multiple mucosal and cutaneous sites [ 16 ]. Malik et al [ 17 ] reported 16 patients with anal involvement and suggested that anal involvement generally occurs in the setting of extensive involvement of PV at other sites.…”