Pemphigus Vulgaris with Lesions of the Rectal Mucosa

Anal Involvement in Pemphigus Vulgaris

“…[8][9][10] These three patients had PV begin in the oral cavity and developed anal lesions at a mean of 15 (range, 2-40) months after disease onset. One of these three previously reported patients had widespread involvement at multiple mucosal and cutaneous sites.…”

“…The following information was collected on each patient: 1) age at onset of PV, 2) time between initial presentation of PV and anal involvement, 3) total duration of anal disease, 4) severity and symptoms of anal disease, 5) number of recurrences if any, 6) systemic treatment, 7) nonanal involvement, 8) length of remission of PV, and 9) total length of follow-up. The authors define remission as the absence of clinical disease after the discontinuation of all systemic therapy.…”

“…The mean duration of the longest episode of anal disease in each patient was eight (range, [3][4][5][6][7][8][9][10][11][12][13][14] weeks. Eleven patients had remission of PV, with the average length of remission at the time of reporting of 27 (range, 6-84) months.…”

“…[4][5][6][7] However, data on anal involvement in PV is limited to three case reports. [8][9][10] This retrospective study presents data on the clinical profile, duration of disease, response to therapy, and details of long-term clinical follow-up in 16 patients with anal involvement of PV.…”

The Gut in Skin Disease: Gastro-Intestinal Manifestations of Selected Skin Disorders

“…Pemphigus vulgaris, a lifethreatening dermatosis, may affect the oe sophagus [18] and the rectum [19], and be nign familial chronic pemphigus (HaileyHailey disease) is a recognised cause of dys phagia [20], Bullous pemphigoid sometimes involves the mucosae and has important as sociations with pernicious anaemia, primary biliary cirrhosis and ulcerative colitis as well as with internal malignancy and other auto immune disturbances. Its dystrophic form, cicatricial pemphigoid, may cause severe generalised scarring of mucous membranes.…”