Pemphigus vegetans: its relationship to eosinophilic spongiosis and favorable response to dapsone

Abstract

Two cases of pemphigus vegetans are presented. One, an example of the Hallopeau type of the disease, was found to have early lesions that simulated eosinophilic spongiosis clinically and histologically. The other had lesions that were largely confined to the oral mucosa and was also considered to be the Hallopeau type of the disease in a limited form. The cases of these two patients were compared with a typical case of eosinophilic spongiosis. All were controlled with dapsone therapy.

Pemphigus vegetans in association with human immunodeficiency virus

“…PV is divided into two clinical subclasses: the Neumann type and the Hallopeau type .7 , 8 Vegetating plaques in both types are characterized by marked acanthosis, extensive papillomatosis, and prominent tissue eosinophilia. A diagnostic finding for both types of PV is the presence of intraepidermal abscesses filled with eosinophils, which was evident in our patient’s biopsy .6 …”

“…The occurrence of autoimmune bullous diseases in the general population is relatively rare. Over the last several years, there have been several reports of autoimmune bullous disease in patients with human immunodeficiency virus (HIV) ( Table 1) .1–6 These entities have included bullous pemphigoid, 1 , 3 epidermolysis bullosa acquisita (EBA), 2 pemphigus herpetiformis, 3 pemphigus vegetans (PV), 4 and pemphigus vulgaris .5 We now report the second case of PV in association with HIV‐1 infection and discuss the relationship between HIV and the development of autoimmune bullous disease.…”

Urticaria as Presenting Manifestation of Pemphigus Herpetiformis

“…Out of about 30 cases found in the literature none had a bad outcome and clinical manifestations were controlled with relatively small doses of steroids [3,4,7,8,10,13] and even by DDS only [5,11,14], Also in our patient, who differs from the other cases of the literature for her young age (most cases being older than 50 years), the disease appears to be easily controlled with small doses of steroids and DDS.…”

Immunologic and Histopathologic Characterization of an Active Disease Mouse Model for Pemphigus Vulgaris

“…Eosinophilic spongiosis in PV model mice PV patients display spongiosis accompanied by eosinophilic cell in®ltrations in early erythematous lesions. This phenomenon is known as`e osinophilic spongiosis'' (Emmerson and Wilson Jones, 1968;Knight et al, 1976;Pearson et al, 1980). To evaluate whether the human histologic changes were reproduced in the PV model mouse, we stained spongiotic sections of both PV model and Dsg3 ±/± mice with Chromotrope 2R.…”