Pemphigus in Brothers

Feldman, Samuel

doi:10.1001/archderm.1936.01470100127014

Cited by 17 publications

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“…HLA typing in the woman and her daughter and sister showed A 26, BW 38 and DRW 4 in all of them. Clinical disease did not develop in the other family members.There have been reports of familial inci dence in pemphigus vulgaris, pemphigus erythematosus, pemphigus foliaceus and pemphigus vegetans [1][2][3][4][5][6], and a high asso ciation of HLA A 26, BW 38 and DRW 4 have also been reported [7,8], We describe here another family occurrence in an uncle and niece of Jewish origin, in which other family members display the typical HLA an tigens but without clinical disease. …”

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confidence: 70%

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Familial Pemphigus vulgaris

Brenner¹,

Dorfman²,

Himelfarb

1985

Dermatology

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A case of familial pemphigus vulgaris is described in an uncle and his niece who developed the disease 18 years apart. The man died from pemphigus in 1964. The diagnosis was confirmed histopathologically in both cases, but immunofluorescent microscopic studies were performed only in the woman because the technique was not available in 1964. HLA typing in the woman and her daughter and sister showed A 26, BW 38 and DRW 4 in all of them. Clinical disease did not develop in the other family members.

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confidence: 70%

“…Lever [9] notes, how ever, that some of them [4,5] Genetic factors may play an important role in the susceptibility to pemphigus. Park et al [8] found HLA antigen DRW 4 in 91% of Jewish pemphigus vulgaris patients, sig nificantly higher than the 25% frequency found among normal Jewish controls.…”

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confidence: 99%