1974
DOI: 10.1001/archderm.110.6.857
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Pemphigus foliaceus. Subcorneal intercellular antibodies of unique specificity

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Cited by 38 publications
(20 citation statements)
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“…Controls included 2 patients with Darier's disease (a nonimmunologically mediated acantholytic disease), 7 patients with bullous pemphigoid (a subepidermal immunologically mediated blistering skin disease), and 19 normal sera. Although none of the sera from PF patients precipitated the PV complex, 14 of the 22 PV sera tested also precipitated the PF complex when extracts and immunoprecipitations were done in the presence of 2 mM calcium (Fig. 2).…”
Section: Resultsmentioning
confidence: 96%
See 1 more Smart Citation
“…Controls included 2 patients with Darier's disease (a nonimmunologically mediated acantholytic disease), 7 patients with bullous pemphigoid (a subepidermal immunologically mediated blistering skin disease), and 19 normal sera. Although none of the sera from PF patients precipitated the PV complex, 14 of the 22 PV sera tested also precipitated the PF complex when extracts and immunoprecipitations were done in the presence of 2 mM calcium (Fig. 2).…”
Section: Resultsmentioning
confidence: 96%
“…In fact, in some cases, PF antibodies have been reported to be located in the superficial epidermis only (14,15).…”
Section: Discussionmentioning
confidence: 99%
“…Immunofluorescence blocking studies performed with sera from four patients with PV and two patients with Brazilian PF (a form of PF endemic to certain areas of Brazil) suggested that PV and PF antibodies bind different antigenic determinants (9). In addition, the report that, by indirect immunofluorescence, some PF sera bound the epidermis in a different pattern than PV sera also, indicates that, at least for those PF sera, there may be an antigenic specificity different from that of PV sera (8). However, antigenic masking may also account for different immunofluorescent patterns of identical antigens.…”
Section: Resultsmentioning
confidence: 96%
“…Although a few patients with PF have been reported to have antibodies that bind only in the superficial epidermis, in general, antibodies from patients with PV and PF bind the cell surface of cells throughout the epidermis in patterns that are indistinguishable (8,9).…”
Section: Introductionmentioning
confidence: 97%
“…Immunofluorescence blocking studies have suggested that antibodies from patients with Brazilian pemphigus foliaceus may have different specificities than antibodies of patients with pemphigus vulgaris (31), however inability of one serum to block the binding of another serum does not prove that these sera bind to different molecules. The presence of several cell surface pemphigus antigens has also been suggested by the observation that different pemphigus sera tested on the same skin specimen may result in different immunofluorescence patterns (32,33). For example, some patients with pemphigus foliaceus have antibodies that only bind the superficial layers of normal epidermis (32).…”
Section: Resultsmentioning
confidence: 98%