Pemphigus and myasthenia gravis

Maize, J. C.

doi:10.1001/archderm.111.10.1334

Cited by 12 publications

(3 citation statements)

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“…The association of superficial pemphigus or pemphigus vulgaris with myasthenia and/or thymoma has been reported over 20 times (Maize et al 1975, Tagami et al 1976). Pemphigus has always followed the onset of myasthenia gravis and has also occurred after thymectomy.…”

Section: Discussionmentioning

confidence: 99%

“…The role of the thymus would seem to be fundamental and the release of hidden antigens following thymic disease is a possible explanation. However, cross reaction between the pemphigus antibody and Hassall's corpuscles has proved negative (Maize et al 1975). Another suggestion is that there is a defect in a group of T cells known as thymic suppressor cells, resulting in a failure to overcome autoimmune phenomena.…”

Section: Discussionmentioning

confidence: 99%

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Cases

Darley

Munro

Borrie

1977

Proceedings of the Royal Society of Medicine

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Cases

Darley

Munro

Borrie

1977

Proceedings of the Royal Society of Medicine

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“…Both PV and PE have been observed in patients with myasthenia gravis [8]. Patients with PF and rheumatoid arthritis have been reported [9].…”

Section: Introductionmentioning

confidence: 99%

Concurrence of Systemic Lupus Erythematosus and Pemphigus: Coincidence or Correlation?

Malik¹,

Ahmed²

2007

Dermatology

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Background: Pemphigus and systemic lupus erythematosus (SLE) have previously been reported to coexist in the same patient. However, the relationship between the 2 diseases has not been elucidated. Objective: This review was conducted to examine the relationship between pemphigus and SLE when they occur together in the same patient. Methods: We conducted a retrospective review of the literature to identify previously reported cases of pemphigus and SLE coexisting in the same patient. The temporal relationship, clinical course, response to therapy and effects of 1 disease on the other were examined. Results: Eight patients with a dual diagnosis of pemphigus and SLE have been previously reported. Most were female and non-Caucasian, with a mean age of 41 years. In the 8 patients reviewed here clinical outcomes, organ system involvement and demographic profiles are more typical of SLE. Seven of these 8 patients had pemphigus vulgaris, and 1 had pemphigus erythematosus. The limited follow-up did not permit studying issues of disease interaction. An additional 17 patients with pemphigus have been reported who have features suggestive of SLE. Organ system involvement in these patients was less typical of SLE. Conclusion: It appears that a true dual diagnosis of pemphigus and SLE is less common than suggested by the literature. Comparing patients with only pemphigus or only SLE to those with both may provide insights into genetic predisposition and pathogenesis, and provide an opportunity to study the effects of drugs that influence their course.

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