Pemphigus and HLA in Morocco

Brick, C.; Belgnaoui, F.; Atouf, O.; Aoussar, A.; Bennani, N.; Senouci, Karima; Hassam, Badreddine; Essakalli, M.

doi:10.1016/j.tracli.2007.10.003

Cited by 21 publications

(27 citation statements)

References 20 publications

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“…However, no association between this allele or any other HLA‐A alleles and PV was found in our study, similar to the study by Brick et al . who did not find any association between HLA‐A antigens and PV.…”

Section: Discussionsupporting

confidence: 91%

Association of human leukocyte antigen class I antigens in Iranian patients with pemphigus vulgaris

Mortazavi

Amirzargar

Esmaili

et al. 2013

The Journal of Dermatology

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There are a limited number of reports indicating the role of human leukocyte antigen (HLA) class I alleles in pemphigus vulgaris. This study was designed to highlight the association of HLA class I alleles with pemphigus vulgaris in Iran. Fifty patients with pemphigus vulgaris, diagnosed based on clinical, histological and direct immunofluorescence findings were enrolled into this study. The control group consisted of 50 healthy, age- and sex-matched individuals. HLA typing of class I (A, B and C alleles) was carried out using polymerase chain reaction based on the sequence-specific primer method. This study showed the higher frequency of HLA-B*44:02 (P = 0.007), -C*04:01 (P < 0.001), -C*15:02 (P < 0.001) and -C*16:01 (P = 0.027) in the patient group, compared to the controls, while the frequency of HLA-C*06:02 (P < 0.001) and -C*18:01 (P = 0.008) in the patients with pemphigus vulgaris was significantly lower than the controls. Regarding the linkage disequilibrium between HLA class I alleles, the HLA-A*03:01, -B*51:01, -C*16:02 haplotype (4% vs 0%, P = 0.04) is suggested to be a predisposing factor, whereas HLA-A*26:01, -B*38, -C*12:03 haplotype (0% vs 6%, P = 0.01) is suggested to be a protective factor. In conclusion, it is suggested that HLA-B*44:02, -C*04:01, -C*15:02 alleles and HLA-A*03:01, -B*51:01, -C*16:02 haplotype are susceptibility factors for development of pemphigus vulgaris in the Iranian population, while HLA-C*06:02, -C*18:01 alleles and HLA-A*26:01, -B*38, -C*12:03 haplotype may be considered as protective alleles.

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Section: Discussionsupporting

confidence: 91%

Association of human leukocyte antigen class I antigens in Iranian patients with pemphigus vulgaris

Mortazavi

Amirzargar

Esmaili

et al. 2013

The Journal of Dermatology

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“…Figure 1 depicts significant associations found across the genome, demonstrating a high concentration of highly associated SNPs near the major histocompatibility complex (MHC) locus. Out of 82 markers that were identified as significantly associated with PV under a controlled false discovery rate of 0.05 (BH), 69 were found to be located on 6p21.3, within the boundaries of the MHC locus (Supplementary Table S1 online), as demonstrated previously in several studies (Miyagawa et al, 2002;Slomov et al, 2003;Brick et al, 2007;Shams et al, 2009;Tunca et al, 2010). The 69 SNPs found on 6p21.3 are distributed within four highly associated peaks 1 6 1 7 1 8 1 9 2 1 2 0 2 2 Figure 1.…”

Section: Genome-wide Association Studysupporting

confidence: 69%

“…HLA-DQA1, HLA-DQB1, and HLA-DRBs loci have been described in association with PV in previous studies in both Jewish and non-Jewish populations (Ahmed et al, 1993;Bordenave et al, 2001;Miyagawa et al, 2002;Slomov et al, 2003;Gazit and Loewenthal, 2004;Tron et al, 2005;Brick et al, 2007;Shams et al, 2009). The other three gene loci have not yet been reported in association with PV but harbor variants predisposing to other inflammatory and/or skin disorders (Simmonds et al, 2006;Fernandez-Morera et al, 2008;Okuyama et al, 2008;Barcellos et al, 2009;Cialfi et al, 2010;Clancy et al, 2010;Hsueh et al, 2010;Jin et al, 2011;Juyal et al, 2011).…”

Section: Genome-wide Association Studymentioning

confidence: 96%

“…A number of candidate gene-driven case-control studies conducted in various populations have revealed associations between pemphigus and HLA class I and II regions, non-HLA genes at the same loci, as well as genes encoding relevant autoantigens (Miyagawa et al, 2002;Gazit and Loewenthal, 2004;Slomov et al, 2005;Tron et al, 2005;Capon et al, 2006;Brick et al, 2007;Javor et al, 2009;Shams et al, 2009;Tunca et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

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Population-Specific Association between a Polymorphic Variant in ST18, Encoding a Pro-Apoptotic Molecule, and Pemphigus Vulgaris

Sarig

Bercovici

Zoller

et al. 2012

Journal of Investigative Dermatology

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Pemphigus vulgaris (PV) is a severe autoimmune blistering disease caused by anti-epithelial antibodies, leading to disruption of cell-cell adhesion. Although the disease is exceedingly rare worldwide, it is known to be relatively prevalent in Jewish populations. The low prevalence of the disease represents a significant obstacle to a genome-wide approach to the mapping of susceptibility genes. We reasoned that the study of a genetically homogeneous cohort characterized by a high prevalence of PV may help exposing associated signals while reducing spurious results due to population sub-structure. We performed a genome-wide association study using 300K single-nucleotide polymorphisms (SNPs) in a case-control study of 100 PV patients of Jewish descent and 397 matched control individuals, followed by replication of significantly associated SNPs in three additional cohorts of Jewish, Egyptian, and German origin. In addition to the major histocompatibility complex locus, a genomic segment on 8q11.23 that spans the ST18 gene was also found to be significantly associated with PV. This association was confirmed in the Jewish and Egyptian replication sets but not in the German sample, suggesting that ST18-associated variants may predispose to PV in a population-specific manner. ST18 regulates apoptosis and inflammation, two processes of direct relevance to the pathogenesis of PV. Further supporting the relevance of ST18 to PV, we found this gene to be overexpressed in the skin of PV patients as compared with healthy individuals.

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“…However, there is variation in the dominant clinical phenotype among countries. PV is the commonest subtype in Egypt (Cairo University hospital records), Sudan, Saudi Arabia, Kuwait, Morocco, Syria and Yemen . PV represents 95.4% in Sudan, 72.2% in Kuwait and 94.7% in southern region of Saudi Arabia of the total pemphigus patients.…”

Section: Types Of Pemphigus In the Arab Worldmentioning

confidence: 99%

Pemphigus in the Arab world

Saleh

2015

The Journal of Dermatology

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The Arab world lies geographically between the Atlantic coasts of northern Africa and the Arabian Gulf. This area has wide latitudinal differences as well as variable environmental conditions ranging from deserts to forests. Approximately 370 million individuals who share the Arabic language live in this area. Pemphigus vulgaris (PV) and pemphigus foliaceus (PF) are the main subtypes of the pemphigus disease. Both pemphigus subtypes are present in many Arab countries; however, there is variation in the predominant subtype among countries. PV is the most common subtype in Egypt, Sudan, Morocco, Syria, Kuwait, Saudi Arabia and Yemen. On the other hand, PF is more prevalent in Libya and is endemic in Tunisia. Interestingly, there is variation in the dominant subtype in some cities within Morocco. For example, PF is more common in Marrakech which is the second largest city. The presence of anti-desmoglein 1 antibodies in the sera of normal Tunisians and the presence of anti-desmoglein 3 in normal Egyptians' sera suggested that environmental factors played a role in the disease pathogenesis in those areas. Further researches detected that traditional cosmetics were among the risk factors in Tunisia. Moreover, farming was suggested as a risk factor in Egypt, Tunisia and Sudan. Because there is no consensus for pemphigus treatment among the Arab countries, there is diversity in their pemphigus treatment regimens. Studying the demographic characteristics and the environmental conditions which caused the variations in the prevailing clinical phenotype will help us fill the gaps to understand the pathogenesis of the pemphigus disease.

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Pemphigus and HLA in Morocco

Cited by 21 publications

References 20 publications

Association of human leukocyte antigen class I antigens in Iranian patients with pemphigus vulgaris

Association of human leukocyte antigen class I antigens in Iranian patients with pemphigus vulgaris

Population-Specific Association between a Polymorphic Variant in ST18, Encoding a Pro-Apoptotic Molecule, and Pemphigus Vulgaris

Pemphigus in the Arab world

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