2013
DOI: 10.1016/s0140-6736(12)61140-4
|View full text |Cite
|
Sign up to set email alerts
|

Abstract: Pemphigoid diseases are a group of well defined autoimmune disorders that are characterised by autoantibodies against structural proteins of the dermal-epidermal junction and, clinically, by tense blisters and erosions on skin or mucous membranes close to the skin surface. The most common of these diseases is bullous pemphigoid, which mainly affects older people and the reported incidence of which in Europe has more than doubled in the past decade. Prognosis and treatments vary substantially between the differ… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1

Citation Types

9
1,145
5
91

Year Published

2015
2015
2019
2019

Publication Types

Select...
8

Relationship

3
5

Authors

Journals

citations
Cited by 855 publications
(1,250 citation statements)
references
References 144 publications
9
1,145
5
91
Order By: Relevance
“…These drugs have been used successfully in various inflammatory disorders, including the autoimmune diseases rheumatoid arthritis and relapsing polychondritis (27). In fact, IL-1b inhibition would be the first therapeutic regimen without unspecific immunosuppressive/ immunomodulative action for AIBDs, such as EBA and bullous pemphigoid (1,28).…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…These drugs have been used successfully in various inflammatory disorders, including the autoimmune diseases rheumatoid arthritis and relapsing polychondritis (27). In fact, IL-1b inhibition would be the first therapeutic regimen without unspecific immunosuppressive/ immunomodulative action for AIBDs, such as EBA and bullous pemphigoid (1,28).…”
Section: Discussionmentioning
confidence: 99%
“…Based on the targeted Ags, AIBDs can be divided into pemphigus and pemphigoid diseases. In pemphigus disease, autoantibodies to desmosomal proteins directly cause blister formation, whereas in pemphigoid disease, blister formation requires the activation of immune mechanisms through the Fc portion of the autoantibodies (1,2). Despite improved therapeutic options, the mortality of patients with pemphigus and pemphigoid remains high (3); this can be attributed, in part, to the extent of immunosuppressive therapy (4).…”
mentioning
confidence: 99%
“…For dermatologists not primarily involved in the care of AIBD patients as well as other physicians, these subtle differences may hardly be appreciated. We therefore advocate to classify pemphigoid diseases based on reactivity against structural proteins of the dermal-epidermal junction rather that against hemidesmosomal proteins [3].…”
Section: Historymentioning
confidence: 99%
“…Pemphigoid diseases are characterized by the presence of autoantibodies against structural proteins of dermalepidermal junction and lead to subepidermal blistering, whereas in pemphigus diseases, autoantibodies against desmosomal proteins are detected causing intraepidermal blister formation. Dermatitis herpetiformis is always associated with celiac disease and characterized by autoantibodies against transglutaminase 2 and 3 [2][3][4].…”
Section: Introductionmentioning
confidence: 99%
“…The cutaneous manifestations of pemphigus subtypes frequently involve the scalp and usually do not present on palms and soles, whereas, as the authors note, in PNP there is "involvement of palms and soles but not the scalp. " Indeed, the involvement of the palms and soles is common in pemphigoid diseases 7 . When PNP affects the oral mucosa, the PNP is far more diffuse and severe than that observed in pemphigus vulgaris, resulting in erosive stomatitis 8 .…”
mentioning
confidence: 99%