Pemoline, Methylphenidate, and Placebo in Children With Minimal Brain Dysfunction

EEG and Clinical Findings during Pemoline Treatment in Children and Adults with Attention Deficit Disorder

“…The present study confirms the previous findings [Conners et al, 1972;Page et al, 1974;Dykman et al, 1974;Conners and Taylor, 1980] of a good clinical response of children with ADD to magnesium pemoline; 8 out of 9 boys showed a significant improvement in con duct problems, learning disabilities, impulsivity, as dem onstrated by parents' ratings, and in attention and mem- ory, as evident by data relative to the psychological tests, and, therefore, were rated as responders by the clinical team. The standardized neurological examination did not show any significant change on treatment.…”

Peer Perceptions of Hyperactivity and Medication Effects

“…There are indications in the literature that adults have detected dysphoric effects of medication (Conners & Taylor, 1980;Gittelman-Klein, Klein, Katz, Saraf, & Pollack, 1976), and we know that the medication effects on the children in the present studies included mild dysphoria (e.g., Whalen & Henker, 1984). What was not known, however, was how peers respond to these relatively subtle indicators of affect.…”

Meta-Analysis: Reduced Risk of Anxiety with Psychostimulant Treatment in Children with Attention-Deficit/Hyperactivity Disorder

“…Authors of 10 additional trials responded to email requests with unpublished data regarding the risks of anxiety in psychostimulant trials. Therefore, a total of 23 trials, involving 2959 subjects, were included in our meta-analysis (Gittelman-Klein et al 1976; Conners and Taylor 1980; Werry et al 1980; Rapport et al 1985; Barkley et al 1990; Ahmann et al 1993; Buitelaar et al 1996; Stein et al 1996; Gillberg et al 1997; Firestone et al 1998; Pliszka et al 2000; Biederman et al 2002; Greenhill et al 2002; McCracken et al 2003; Stein et al 2003; Wigal et al 2004; Gorman et al 2006; Spencer et al 2006; Wigal et al 2006; Newcorn et al 2008; Childress et al 2009; Solanto et al 2009; Lee et al 2011). The characteristics of included trials are depicted in Table 1.…”