PEM-2400 - a biopsy-ready PEM scanner with real-time X-ray correlation capability

Weinberg, I.; Stepanov, P.Yu.; Beylin, David; Zavarzin, V.; Anashkin, Edward; Lauckner, K.; Yarnall, S.; Doss, Mohan; Pani, R.; Adler, Lee P.

doi:10.1109/nssmic.2002.1239520

Cited by 12 publications

(11 citation statements)

References 2 publications

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“…Other configurations are also being investigated [7,31] to overcome such limitations. A possible solution proposed for obtaining pseudo-tomography acquisition is the translation of rectangular detectors in a fixed position [32].…”

Section: State-of-the-art In Dedicated Pem Systemsmentioning

confidence: 99%

State-of-the-art of PET scanners for small animal and breast cancer imaging

Guerra

Belcari

2007

Nuclear Instruments and Methods in Physics Research Section A:

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Section: State-of-the-art In Dedicated Pem Systemsmentioning

confidence: 99%

State-of-the-art of PET scanners for small animal and breast cancer imaging

Guerra

Belcari

2007

Nuclear Instruments and Methods in Physics Research Section A:

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“…Combining the two equations and solving for we find: (7) where and has been substituted. A similar equation can be determined for : (8) In our application these equations are the equations of relevance.…”

Section: B Stereotactic Calculationmentioning

confidence: 99%

“…The Y-location of the region of interest is the difference between the Y-value of this fiducial marker source and Y-value of the region of interest. The X-location of the region of interest is calculated from the difference in the X-value of this fiducial marker source and the X-value of the region of interest from (7). Similarly, the Z-value is calculated from (8).…”

Section: Fiducial Marker For Spatial Calibration Of the Gamma Ray mentioning

confidence: 99%

“…The collimator hole diameter was 1.4 mm, the length was 27 mm and the septa thickness was 0.2 mm [7], [10]. The axial dependence of the spatial resolution was determined from a measurement of the pixel full-width at half-maximum intensity (FWHM) of the image of a point source located at various distances from the gamma ray camera.…”

Section: Collimator Spatial Resolutionmentioning

confidence: 99%

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Gamma-Guided Stereotactic Breast Biopsy System

Welch

Brem²,

Kross

et al. 2006

IEEE Trans. Nucl. Sci.

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A gamma-ray imaging system has been developed for acquiring stereo images of the distribution of radiopharmaceuticals in breast tissue. The system consists of a small field-of-view gamma-ray camera mounted to a stereotactic biopsy table. The camera is mounted on a rotational arm such that it can be used to image the breast from two 15 stereo views. These stereo images can be used to determine the three dimensional spatial location of a region of focal uptake. Once the location of this region is determined, this information can be used as a guide for stereotactic core needle biopsy. The accuracy that the spatial location of a source can be determined was investigated by moving a point source within the field of view. A center-of gravity calculation was used to localize the centroid of the image of the source and this was used to determine the spatial location. Measurements indicate that the source can be localized to within 1 mm. A comparison of the operation of the gamma imaging system and an x-ray imaging system has been done using a dual modality phantom. These measurements indicated that the spatial location of an isolated source can be determined by the gamma imaging system to within approximately the same performance criteria as required for the X-ray system (1 mm). Collimators were tested to determine the spatial resolution in the transverse dimension and the impact of this transverse resolution on the axial resolution was investigated. The performance of this gamma-guided stereotactic biopsy system will be presented.

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“…Other dedicated PET scanners are being developed for breast cancer [2]- [8] and prostate cancer [9]. The design concept of using high-resolution detector inserts in coincidence with general-purpose whole-body PET scanners, proposed by Tai, et al [10], may provide a more cost-efficient way to achieve high-resolution PET images within a smaller field-of-view (FOV).…”

Section: Introductionmentioning

confidence: 99%

A simulation study for the design of a prototype insert for whole-body PET scanners

Janecek

Tai

2006

IEEE Trans. Nucl. Sci.

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We are developing an insert device that will improve image resolution within a smaller field-of-view for clinical wholebody PET scanners. We modified SimSET (Simulation System for Emission Tomography) to simulate the insert and a PET scanner. The system consists of two detector rings. The inner ring represents an insert (r = 153 mm) with high-resolution detectors using 10 mm thick LSO. The outer ring represents a PET scanner (R = 413 mm) with 25 mm thick LSO. Events were binned into three sets of sinograms assuming a 2.4 and 6.75 mm crystal-pitch for the insert and the PET scanner, respectively. The detectors in the insert are modeled as 1, 2, or 4 layers with different offset configurations to evaluate the corresponding system resolution with the depth-ofinteraction (DOI) effect. Results show that image resolution at 1 cm radial offset is improved from 5.6 mm full-width-at-half-maximum (FWHM) of the original PET scanner to 2.0 mm with the insert. At 12 cm offset, the resolution of the original system is 5.9 and 5.5 mm for radial and tangential directions, respectively. With the insert, the radial resolution is 5.0 mm FWHM for a single-layer detector design, but improves to 2.7 and 2.2 mm for 2-and 4-layer DOI detectors, respectively. Different offsets for multi-layer detectors have negligible effect on resolution. Sensitivity of the device is, assuming the insert has a 2 cm axial extend, estimated to be 3.3%, including coincidence events from the insert-alone and insert-to-scanner sinograms. In contrast, if the insert is used as a stand-alone microPET scanner, its sensitivity is 1.3%.Index Terms-Depth of interaction (DOI), head and neck imaging, high resolution imaging, Monte Carlo simulations, pseudo pinhole positron emission tomography (PET).

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PEM-2400 - a biopsy-ready PEM scanner with real-time X-ray correlation capability

Cited by 12 publications

References 2 publications

State-of-the-art of PET scanners for small animal and breast cancer imaging

State-of-the-art of PET scanners for small animal and breast cancer imaging

Gamma-Guided Stereotactic Breast Biopsy System

A simulation study for the design of a prototype insert for whole-body PET scanners

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