PEGylated Prussian blue nanoparticles for modulating polyethyleneimine cytotoxicity and attenuating tumor hypoxia for dual-enhanced photodynamic therapy

Abstract

Photodynamic therapy (PDT) is a promising cancer therapy modality due to its intrinsically negligible side effects and treatment resistance. However, the development of the high-efficiency PDT still remains a challenge....

Cancer nanomedicine: a review of nano-therapeutics and challenges ahead

“…Besides, better therapeutic efficacy was observed in breast cancer cells and tumor-bearing mice after laser irradiation. 51 In another study, evident cell apoptosis and necrosis were observed in PEGylated nanographene oxide-treated cancer cells and this study is an example of combination therapy. 52 A recently published paper examined an iron-dependent regulated cell death process (ferroptosis) by liposomes embedded with PEG-coated 3 nm γ-Fe 2 O 3 nanoparticles in the bilayer.…”

The multifunctional Prussian blue/graphitic carbon nitride nanocomposites for fluorescence imaging-guided photothermal and photodynamic combination therapy

“…S1c,† the fine energy spectrum of O 1s had two absorption peaks at 531.9 eV and 533.4 eV, attributing to the CO and the binding energy of the C–O bond, respectively. 34 In the fine energy spectrum of Fe 2p (Fig. S1d†), five characteristic peaks were observed at 708 eV, 710.1 eV, 712.3 eV, 721.5 eV, and 724.4 eV, respectively, which were attributed to Fe–N, Fe 2+ 2p 3/2 , Fe 3+ 2p 3/2 , Fe 2+ 2p 1/2 and Fe 3+ 2p 1/2 .…”

Polyethyleneimine-Based Drug Delivery Systems for Cancer Theranostics

“…PEI-based drug delivery systems are also used for other therapies, such as photothermal therapy (PTT), photodynamic therapy (PDT), immunotherapy, and combination therapy [ 159 , 160 , 161 , 162 , 163 , 164 ]. For example, Huang et al reported that PEI-coated oxidized mesoporous carbon nanospheres were designed for combined PTT and gene therapy of tumors [ 154 ].…”