PEGylated Poly(Lactide-co-Glycolide) (PLGA) Nanoparticulate Delivery of Docetaxel: Synthesis of Diblock Copolymers, Optimization of Preparation Variables on Formulation Characteristics and In Vitro Release Studies

Potent Engineered PLGA Nanoparticles by Virtue of Exceptionally High Chemotherapeutic Loadings

“…Encapsulation efficiency is >90% for all compositions. Others have cited lowered encapsulation efficiency as drug loading increases; 26 however, with the PRINT process loading does not affect encapsulation nor does it affect the particle's physical properties. The largest dimension of the 200 nm  200 nm cylinder is approximately 280 nm and the smallest 200 nm, which is reflected in the size measured by dynamic light scattering (DLS) and is consistent across all compositions (Table 2).…”

Elaboration of sponge-like biodegradable cationic particles via double-emulsion solvent evaporation

“…[34,35] Diverse methods are explored for the encapsulation of various active molecules and the nature of the drug [36] is generally the deciding factor for the selection of the encapsulation technique [37] . The most commonly used encapsulation methods include; single emulsion process, [38] double emulsion process, solvent diffusion, [39] organic phase separation, supercritical fluid technology, spray drying [34,40] and miniemulsion polymerization [41] techniques. Few important parameters must be taken into consideration before designing any new technique like stability and biological activity of the drugs should remain unaltered during encapsulation process, encapsulation efficiency should be high, microparticles quality and drug release profile should be reproducible and aggregation of microparticles should be prevented.…”