Peek dental implants coated with boron-doped nano-hydroxyapatites: Investigation of in-vitro osteogenic activity

Bozoğlu, Ü.  Çayır; Kiremitçi, Arlin; Yurtsever, Merve Çapkın; Gümüşderelı́oğlu, Menemşe

doi:10.1016/j.jtemb.2022.127026

Cited by 7 publications

(5 citation statements)

References 41 publications

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“…Sulfonated PEEK dental implants have been functionalized with boron-doped hydroxyapatite nanoparticles. Compared to unmodified PEEK, sulfonated PEEK substrates showed a significant improvement in adhesion, proliferation, and osteogenic differentiation of periodontal ligament cells in in vitro cell culture experiments [34].…”

Section: Sulfonationmentioning

confidence: 94%

“…In the dental implant field, PEEK has been considered a strong candidate to substitute the gold standard, titanium, due to its superior esthetics and elastic modulus, which are comparable to the bulk properties of human bones [31,33]. While Ti and its alloys exhibit a high elastic modulus (110 GPa), PEEK has an elastic modulus (3-4 GPa) similar to human cortical bone [34], preventing adverse stress-shielding effects [35,36]. Furthermore, PEEK is radiolucent, which is beneficial for monitoring osseointegration progress using imaging techniques such as X-rays.…”

Section: The Superior Properties Of Peekmentioning

confidence: 99%

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Surface Modifications of High-Performance Polymer Polyetheretherketone (PEEK) to Improve Its Biological Performance in Dentistry

Pidhatika

Widyaya²,

Nalam

et al. 2022

Polymers

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This comprehensive review focuses on polyetheretherketone (PEEK), a synthetic thermoplastic polymer, for applications in dentistry. As a high-performance polymer, PEEK is intrinsically robust yet biocompatible, making it an ideal substitute for titanium—the current gold standard in dentistry. PEEK, however, is also inert due to its low surface energy and brings challenges when employed in dentistry. Inert PEEK often falls short of achieving a few critical requirements of clinical dental materials, such as adhesiveness, osseoconductivity, antibacterial properties, and resistance to tribocorrosion. This study aims to review these properties and explore the various surface modification strategies that enhance the performance of PEEK. Literatures searches were conducted on Google Scholar, Research Gate, and PubMed databases using PEEK, polyetheretherketone, osseointegration of PEEK, PEEK in dentistry, tribology of PEEK, surface modifications, dental applications, bonding strength, surface topography, adhesive in dentistry, and dental implant as keywords. Literature on the topics of surface modification to increase adhesiveness, tribology, and osseointegration of PEEK were included in the review. The unavailability of full texts was considered when excluding literature. Surface modifications via chemical strategies (such as sulfonation, plasma treatment, UV treatment, surface coating, surface polymerization, etc.) and/or physical approaches (such as sandblasting, laser treatment, accelerated neutral atom beam, layer-by-layer assembly, particle leaching, etc.) employed in the literature are summarized and compared. Further, approaches such as the incorporation of bioactive materials, e.g., osteogenic agents, antibacterial agents, etc., to enhance the abovementioned desired properties are explored. This review presents surface modification as a critical and essential approach to enhance the biological performance of PEEK in dentistry by retaining its mechanical robustness.

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Section: Sulfonationmentioning

confidence: 94%

Section: The Superior Properties Of Peekmentioning

confidence: 99%

Surface Modifications of High-Performance Polymer Polyetheretherketone (PEEK) to Improve Its Biological Performance in Dentistry

Pidhatika

Widyaya²,

Nalam

et al. 2022

Polymers

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show abstract

“…Different types of coatings may be used to improve osseointegration-bioactive ions, calcium phosphate, proteins, aforementioned peptides, and natural biopolymers like hyaluronic acid (HA) [85,86]. Synthetic hydroxyapatite (HA) may be used as a coating or as a reinforcing phase enhancing the bioactivity of PEEK [41,[87][88][89]. According to Mishra et al and other authors surface modifications of PEEK enhance biocompatibility, cell adhesion, cell proliferation, and osseointegration [90].…”

Section: Peekmentioning

confidence: 99%

Comparative Analysis of the Mechanical Properties and Biocompatibility between CAD/CAM and Conventional Polymers Applied in Prosthetic Dentistry

Chuchulska,

Dimitrova,

Vlahova

et al. 2024

Polymers

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Modern media often portray CAD/CAM technology as widely utilized in the fabrication of dental prosthetics. This study presents a comparative analysis of the mechanical properties and biocompatibility of CAD/CAM (Computer-Aided Design/Computer-Aided Manufacturing) polymers and conventional polymers commonly utilized in prosthetic dentistry. With the increasing adoption of CAD/CAM technology in dental laboratories and practices, understanding the differences in material properties is crucial for informed decision-making in prosthodontic treatment planning. Through a narrative review of the literature and empirical data, this study evaluates the mechanical strength, durability, esthetics, and biocompatibility of CAD/CAM polymers in comparison to traditional polymers. Furthermore, it examines the implications of these findings on the clinical outcomes and long-term success of prosthetic restorations. The results provide valuable insights into the advantages and limitations of CAD/CAM polymers, informing clinicians and researchers about their suitability for various dental prosthetic applications. This study underscores the considerable advantages of CAD/CAM polymers over conventional ones in terms of mechanical properties, biocompatibility, and esthetics for prosthetic dentistry. CAD/CAM technology offers improved mechanical strength and durability, potentially enhancing the long-term performance of dental prosthetics, while the biocompatibility of these polymers makes them suitable for a broad patient demographic, reducing the risk of adverse reactions. The practical implications of these findings for dental technicians and dentists are significant, as understanding these material differences enables tailored treatment planning to meet individual patient needs and preferences. Integration of CAD/CAM technology into dental practices can lead to more predictable outcomes and heightened patient satisfaction with prosthetic restorations.

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“… Sharifi et al, 2022 [88] In-vitro study Formed and analyzed the properties of a novel root repair material with nHA, Portland cement, and bismuth oxide. There was a significant increase in cell viability in the novel root repair material containing hydroxyapatite nanoparticles after 3 and 7 days Bozoglu et al, 2022 [89] In-vitro Osteogenic potential of PEEK implants coated with boron doped nHA on periodontal ligament cells Enhanced periodontal ligament cells adhesion and proliferation on the surface of PEEK implants coated with boron doped nHA compared with untreated PEEK implants Ji, D. and Lu, D 2022 [90] In-vitro and Animal study Effect of nHA composite polyamide 66 at the interface between bone tissue and titanium implants on repairing type II diabetics bone defects Enhanced bone repair nHA composite polyamide 66 material showed enhance bone repair between bone and implant. The material had good biocompatibility and less cytotoxicity Karthika, 2022 [91] In vitro Fe (III) and Cu (II) incorporated hydroxyapatite coatings (Fe/Cu-HAP) on titanium implant was developed and assessed for biocompatibility and antibacterial activity Fe/Cu-HAP coating on titanium implant showed uniform deposition with improved biocompatibility and bioactivity.…”

Section: Introductionmentioning

confidence: 96%

Nanohydroxyapatite in dentistry: A comprehensive review

Pushpalatha

Gayathri

Sowmya

et al. 2023

The Saudi Dental Journal

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Peek dental implants coated with boron-doped nano-hydroxyapatites: Investigation of in-vitro osteogenic activity

Cited by 7 publications

References 41 publications

Surface Modifications of High-Performance Polymer Polyetheretherketone (PEEK) to Improve Its Biological Performance in Dentistry

Surface Modifications of High-Performance Polymer Polyetheretherketone (PEEK) to Improve Its Biological Performance in Dentistry

Comparative Analysis of the Mechanical Properties and Biocompatibility between CAD/CAM and Conventional Polymers Applied in Prosthetic Dentistry

Nanohydroxyapatite in dentistry: A comprehensive review

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