Pediatric Nutrition Needs Met With A High Calorie Peptide-based Enteral Formula

Nutritional Support in Malnourished Children With Compromised Gastrointestinal Function: Utility of Peptide-Based Enteral Therapy

“…Presence of compromised gastrointestinal function in malnourished children is critical given that alterations such as malabsorption and increased intestinal permeability directly interfere with efficacy of nutritional support and recovery from malnutrition ( 14 ). Nutritional therapy in children with compromised gastrointestinal function is therefore should involve gut-protective interventions that address the overlapping and interacting effects of diarrhea, enteropathy and malnutrition to improve child survival and developmental potential in the long-term ( 3 , 25 , 35 ). Peptide-based enteral formulas seem to have clinical applications in malnourished children with different levels of compromised gastrointestinal function, given their association with improved gastrointestinal tolerance and absorption, better nitrogen retention/ balance, reduced diarrhea and bacterial translocation, enhanced MCT-based fat absorption and maintained/restored gut integrity as compared with free amino acid or whole-protein formulas ( 34 , 36 , 61 , 63 , 66 , 68 , 69 ).…”

“…The adverse impact of metabolic stress and illness on the gut integrity increase the risk of malnutrition via loss of appetite, increased intestinal permeability, diarrhea, and malabsorption of nutrients, whereas those at risk for malnutrition are already at risk for compromised gut function including mucosal intestinal abnormalities and malabsorption of nutrients and vitamins (3,34). Accordingly, bidirectional interplay between malnutrition and compromised gastrointestinal function emphasizes the importance of appropriate nutritional support in malnourished children that addresses the overlapping and interacting effects of diarrhea, enteropathy, and malnutrition to improve child survival and developmental potential in the long-term (3,25,35).…”

“…Accordingly, bidirectional interplay between malnutrition and compromised gastrointestinal function emphasizes the importance of appropriate nutritional support in malnourished children that addresses the overlapping and interacting effects of diarrhea, enteropathy, and malnutrition to improve child survival and developmental potential in the long-term ( 3 , 25 , 35 ).…”

“…These findings suggest that the enhanced absorption of protein in the form of a protein hydrolysate and its effect on ureagenesis may have clinical applications in patients with compromised gastrointestinal functions such as impaired digestion or absorption and those with a protein losing enteropathy ( 36 , 63 ). Indeed, failure to thrive (transitional feeding) is considered amongst the indications for use of a peptide based formula ( 36 , 63 ), and the benefit of enteral therapy with peptide-based formulas was also reported in children with compromised gastrointestinal function ( 35 ).…”

Clinical Case Reports on the acceptability and tolerance of a High‐Energy whey peptide‐based Pediatric oral nutritional supplement in children aged over 12 months

“…Features of Cockayne syndrome include a failure to gain weight and growth at the expected rate (failure to thrive), abnormally small head size (microcephaly), and impaired development of the nervous system 28,29 . Malnutrition in children leads to impaired growth and development and worse clinical outcomes 30 . In children with neurological impairment and compromised GI function who require EN with a semi‐elemental formula (N = 8), switching from another semi‐elemental formula to a Peptamen Junior formula containing 1.5 kcal/ml* for 21 days resulted in increased calorie intake, such that patients met their calorie intake goals 31 …”