Pediatric Norovirus Diarrhea in Nicaragua

Bucardo, Filemón; Nordgren, Johan; Carlsson, Beatrice; Paniagua, Margarita; Lindgren, Per-Eric; Espinoza, Félix; Svensson, Lennart

doi:10.1128/jcm.00505-08

Cited by 86 publications

(106 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This is due to norovirus causing less severe diarrhoea than rotavirus and parents tend not to seek medical services [25,26]. In our study, the severity of diarrhoea episodes was similar in children with and without NoV and similar high detection rates had been reported from Chile, India and Nicaragua at that time when the vaccines had not been introduced [18][19][20].…”

Section: Discussionsupporting

confidence: 82%

“…Globally, hospital-based series in children with diarrhoea report a median of 14%, which seems lower than the proportions detected in our study [17]. Although our data suggests an annual increase in the proportion of cases, similar detection rates had been reported from Chile, India and Nicaragua prior to rotavirus vaccine introduction [18][19][20]. This relative increase may also be due to the decrease of number of rotavirus-related hospitalizations [10,11] and all-cause diarrhoea cases due to the effectiveness of the rotavirus vaccine [21] and the herd effect of the vaccine that has resulted in an overall and not a real increase in the overall number of NoV cases.…”

Section: Discussioncontrasting

confidence: 60%

See 1 more Smart Citation

Acute norovirus gastroenteritis in children in a highly rotavirus-vaccinated population in Northeast Brazil

Santos

Gurgel

Cavalcante

et al. 2017

Journal of Clinical Virology

View full text Add to dashboard Cite

Running title: Norovirus diarrhoea in children in BrazilWord count: Abstract: 199. Manuscript: 2255. Highlights Gastroenteritis is one of the most important causes of morbidity and mortality in children.  Noroviruses are a leading cause of sporadic cases and outbreaks of acute gastroenteritis.  Norovirus annual detection rates increased over the study period.  The detection of norovirus was higher among young children. AbstractBackground: Gastroenteritis is one of the most important causes of morbidity and mortality

show abstract

Section: Discussionsupporting

confidence: 82%

Section: Discussioncontrasting

confidence: 60%

Acute norovirus gastroenteritis in children in a highly rotavirus-vaccinated population in Northeast Brazil

Santos

Gurgel

Cavalcante

et al. 2017

Journal of Clinical Virology

View full text Add to dashboard Cite

show abstract

“…In other recent studies GII.4 strains were detected even more frequently ranging from 62.7% to 68%. 13,36,37 This is the first report of GII. 4 The data suggests that 80% of the NoV infections in this study were community acquired.…”

Section: Discussionmentioning

confidence: 79%

“…These results are similar to studies in Brazil, Nicaragua and Tunisia where the predominance of the GII strains in hospitalised children with gastroenteritis (88-96% of NoV positive specimens) was also noted. 13,36,37 However, other studies in Brazil 39 and Mexico 40 found GI and GII strains at comparable frequencies. These studies were conducted over different time intervals several years ago (1998 and 1998-2005) and used different study populations.…”

Section: Discussionmentioning

confidence: 82%

“…NoVs were detected only in children up to 2 years old (median age 8 months), which is in agreement with studies in Brazil and Nicaragua where more frequent NoV infections in children ≤2 years old were reported. 36,37 This could indicate that short term immunity is generated to NoV, since NoV infections in older children and adults are common. 38 Alternatively, NoV infections in infants could cause more serious symptoms that require hospitalisation whereas older children may not be as severely affected.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Emerging norovirus GII.4 2008 variant detected in hospitalised paediatric patients in South Africa

Mans

Villiers

Plessis

et al. 2010

Journal of Clinical Virology

View full text Add to dashboard Cite

a b s t r a c tBackground: Noroviruses (NoVs) are important enteric pathogens that cause gastroenteritis worldwide. The first documented NoV outbreaks in South Africa (SA) were described in 1993. The current NoV prevalence and circulating genotypes are unknown. SA lacks NoV outbreak reporting systems and therefore the number and impact of NoV infections is underestimated. Objectives: This study aimed to determine the prevalence and genetic diversity of NoV infections in hospitalised paediatric patients with gastroenteritis in SA during 2008. Study design: Stool specimens referred for virological analysis from hospitalised children ≤13 years, with gastroenteritis, were screened for rotavirus, human adenovirus and human astrovirus by enzyme immunoassay and for NoV genogroup I (GI), II (GII) and sapovirus by real-time RT-PCR. NoV strains were genotyped, and variants identified, based on sequence and phylogenetic analyses of the 5 end or the full length of the capsid gene, respectively. Results: Rotavirus was the most prevalent virus detected in 24.2% (61/252) of specimens, followed by NoV in 14.3% (35/245) and adenovirus, astrovirus and sapovirus in 9.6%, 6.7% and 4% of specimens, respectively. NoVs were only detected in children ≤2 years. The GII NoVs (89%) predominated and eight types were identified with GII.4 (43%) detected most frequently. The emerging 2008 GII.4 variant represented 80% of the GII.4 strains. Conclusions: A diverse range of NoV genotypes were identified in hospitalised children with gastroenteritis. The 2008 GII.4 variant was the most frequently detected strain in the study. This is the first report of NoV GII.4 viruses in SA.

show abstract