Pediatric Neuromyelitis Optica Spectrum Disorder

Poisson, Kelsey E.; Moeller, Karen E.; Fisher, Kristen

doi:10.1016/j.spen.2023.101051

Cited by 2 publications

(1 citation statement)

References 71 publications

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“…[2] Paediatric optic neuritis accounts for 25% of acute demyelinating syndromes in this age group. [3,4] Post-infectious (usually viral) or postimmunisation aetiologies usually predominate. [5] Less commonly, it may be the first manifestation of multiple sclerosis (MS) or other diffuse demyelinating disorders such as acute demyelinating encephalomyelitis (ADEM), NMOSD and myelin oligodendrocyte glycoprotein-associated disease (MOGAD).…”

Section: In Practicementioning

confidence: 99%

Acute gastroenteritis and unilateral vision loss leading to a diagnosis of aquaporin-4-IgG seropositive neuromyelitis optica spectrum of disorders in a child: A case of atypical optic neuritis in the era of biomarkers

Narainswami

2024

S Afr Med J

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Neuromyelitis optica spectrum of disorders is a rare cause of optic neuritis in children. It is a critical diagnosis requiring urgent management, with delays carrying both life- and sight-threatening complications. Most of the published literature on this entity is in adult patients, with only a few case reports to guide management in the paediatric population. The purpose of this article is to shareour experience in the management of this condition in a child, and thus hopefully add to the limited body of knowledge currently available.

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Section: In Practicementioning

confidence: 99%

Acute gastroenteritis and unilateral vision loss leading to a diagnosis of aquaporin-4-IgG seropositive neuromyelitis optica spectrum of disorders in a child: A case of atypical optic neuritis in the era of biomarkers

Narainswami

2024

S Afr Med J

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Neuromyelitis optica spectrum disorders in children

Akhmetgaleeva,

Simaniv,

Yausheva

et al. 2024

RJTAO

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In recent decades, the prevalence of demyelinating diseases in paediatric patients has increased rapidly. In this context, there is an increasing need for the study of this pathology in children to enable timely diagnosis and early prescription of highly effective pathogenetic treatment. Neuromyelitis optica spectrum disorders (NMOSD) are a group of severe demyelinating disorders that are united by a single pathogenetic mechanism and primarily affection of the optic nerves and spinal cord. The review presents the main clinical and epidemiological features of NMOSD in the paediatric population. The issues of pathogenesis, which is based on the formation of antibodies against aquaporin-4, and possible therapeutic targets are discussed in detail. The diagnostic criteria and the underlying clinical manifestations as well as their characteristics in childhood are analysed. We present a differential diagnostic framework of the most common diseases, which have to be distinguished from NMOSD in children. Particular attention is paid to the pathogenetic treatment of exacerbations and targeted therapy to prevent exacerbations, which has relatively recently proven its efficacy and been approved for use in paediatric patients.

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Pediatric Neuromyelitis Optica Spectrum Disorder

Cited by 2 publications

References 71 publications

Acute gastroenteritis and unilateral vision loss leading to a diagnosis of aquaporin-4-IgG seropositive neuromyelitis optica spectrum of disorders in a child: A case of atypical optic neuritis in the era of biomarkers

Acute gastroenteritis and unilateral vision loss leading to a diagnosis of aquaporin-4-IgG seropositive neuromyelitis optica spectrum of disorders in a child: A case of atypical optic neuritis in the era of biomarkers

Neuromyelitis optica spectrum disorders in children

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