2014
DOI: 10.1371/journal.pone.0089102
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Abstract: BackgroundThere exist significant challenges to the receipt of comprehensive oncologic treatment for children diagnosed with cancer in sub-Saharan Africa. To better define those challenges, we investigated treatment outcomes and risk factors for treatment abandonment in a cohort of children diagnosed with cancer at the University Teaching Hospital (UTH), the site of the only pediatric oncology ward in Zambia.MethodsUsing an established database, a retrospective cohort study was conducted of children aged 0–15 … Show more

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Cited by 74 publications
(128 citation statements)
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“…[1][2][3][4] Survival rates in high-income countries are up to 80%, while most countries in Africa have survival rates less than 30%. [5][6][7] This scenario has been attributed to many factors including difficulties in accessing hospital, paucity of trained personnel, lack of investigational and treatment capabilities as well as late presentation. 1,2,6,7 Early diagnosis of cancer is a fundamental goal in cancer care because it gives opportunity for timely initiation of appropriate treatment, while the disease is at its earliest stages.…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…[1][2][3][4] Survival rates in high-income countries are up to 80%, while most countries in Africa have survival rates less than 30%. [5][6][7] This scenario has been attributed to many factors including difficulties in accessing hospital, paucity of trained personnel, lack of investigational and treatment capabilities as well as late presentation. 1,2,6,7 Early diagnosis of cancer is a fundamental goal in cancer care because it gives opportunity for timely initiation of appropriate treatment, while the disease is at its earliest stages.…”
Section: Introductionmentioning
confidence: 99%
“…[5][6][7] This scenario has been attributed to many factors including difficulties in accessing hospital, paucity of trained personnel, lack of investigational and treatment capabilities as well as late presentation. 1,2,6,7 Early diagnosis of cancer is a fundamental goal in cancer care because it gives opportunity for timely initiation of appropriate treatment, while the disease is at its earliest stages. Early diagnosis and start of treatment may improve prognosis and allow cure to be achieved with minimal side-effects.…”
Section: Introductionmentioning
confidence: 99%
“…2 However, we found very little information on treatment abandonment rates for children with brain tumors in developing countries. 14,15 To our knowledge, our study is the first to report on abandonment of medulloblastoma treatment for children in China. The abandonment rate was 31% in this cohort.…”
Section: Discussionmentioning
confidence: 77%
“…19,20,21 It is evident from this study that many family members and parents of children with cancer persist through challenges and ultimately get their children to tertiary paediatric oncology centres.…”
Section: Discussionmentioning
confidence: 94%