Pediatric Hospitalizations Associated with 2009 Pandemic Influenza A (H1N1) in Argentina

Libster, Romina; Bugna, Jimena; Coviello, Silvina; Hijano, Diego R.; Dunaiewsky, Mariana; Reynoso, Natalia Ordaz; Cavalieri, Maria L.; Guglielmo, María Cecilia; Areso, María Soledad; Gilligan, T. A.; Santucho, Fernanda; Cabral, Graciela; Gregorio, Gabriela L.; Moreno, Rina; Lutz, Maria I.; Panigasi, Alicia L.; Saligari, Liliana; Caballero, Mauricio T.; Almeida, Rodrigo M. Egües; Meyer, Maria Emilia Gutierrez; Neder, Maria D.; Davenport, Carolina; Valle, Matheus Ribeiro do; Santidrian, Valeria S.; Mosca, Guillermina; Domínguez, Mercedes Garcia; Álvarez, Liliana Quintero; Landa, Patricia; Pota, Ana; Boloñati, Norma; Dalamón, Ricardo; Mercol, Victoria I. Sanchez; Espinoza, Marco A.; Peuchot, Juan Carlos; Karolinski, Ariel; Bruno, Miriam; Borsa, Ana; Ferrero, Fernando; Bonina, Angel; Ramonet, Margarita; Albano, Lidia; Luedicke, Nora; Alterman, Elías; Savy, Vilma L.; Baumeister, Elsa; Chappell, James D.; Edwards, Kathryn M.; Melendi, Guillermina A.; Polack, Fernando P.

doi:10.1056/nejmoa0907673

Cited by 348 publications

(418 citation statements)

References 18 publications

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“…Libster and colleagues also reported higher hospitalization rates due to H1N1 infection among Argentinean children. In Argentina, the rates of hospitalization for H1N1 were double those for seasonal infl uenza in 2008 13 . We observed a similar increase in hospitalization rates in our sample, demonstrating that the emergence of H1N1 had a major impact on our health system.…”

Section: Number Suspicious/confirmed Casesmentioning

confidence: 99%

“…Whereas seasonal infl uenza had case lethality rates of approximately 5%, the lethality rate of H1N1 was 7.1%. Other studies have also noted that infl uenza A (H1N1) is associated with substantial pediatric mortality 13,15 . The important tools for minimizing the severity of infection in children include antiviral therapy, particularly in patients with preexisting neurological disorders or chronic lung disease, and vaccination.…”

Section: Number Suspicious/confirmed Casesmentioning

confidence: 99%

See 1 more Smart Citation

Viral epidemiology of respiratory infections among children at a tertiary hospital in Southern Brazil

de‐Paris

Beck

Pires

et al. 2014

Rev. Soc. Bras. Med. Trop.

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Section: Number Suspicious/confirmed Casesmentioning

confidence: 99%

Section: Number Suspicious/confirmed Casesmentioning

confidence: 99%

Viral epidemiology of respiratory infections among children at a tertiary hospital in Southern Brazil

de‐Paris

Beck

Pires

et al. 2014

Rev. Soc. Bras. Med. Trop.

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“…The clinical manifestations of 2009 pandemic influenza A (H1N1) greatly varied. While the mild‐form 2009 pandemic influenza A (H1N1) with nonspecific symptoms/signs such as fever, sore throat, and myalgia are usually found, severe cases with fatal outcome have not been uncommonly encountered 5 , 6 , 7 , 8 , 9 , 10 . The first case of pandemic influenza A (H1N1) was identified in Taiwan on May 20, 2009 11 .…”

Section: Introductionmentioning

confidence: 99%

2009 pandemic Influenza A (H1N1): clinical and laboratory characteristics in pediatric and adult patients and in patients with pulmonary involvement

Lee

Liu

Wang

et al. 2012

Influenza Resp Viruses

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Please cite this paper as: Lee and Liu et al. (2012) 2009 pandemic Influenza A (H1N1): clinical and laboratory characteristics in pediatric and adult patients and in patients with pulmonary involvement. Influenza and Other Respiratory Viruses 6(601), e152–e161. Background To better understand clinical and laboratory characteristics in children, adults, and patients with lung involvement suffering 2009 pandemic influenza A (H1N1). Methods A total of 442 patients with 2009 pandemic influenza A (H1N1) were retrospectively analyzed. Results Comparing to their adult counterpart (n = 55), pediatric patients (n = 387) had significantly higher frequencies of fever, rhinorrhea, cough, sore throat, nausea/vomiting, and longer length of fever; lower frequencies of chest pain and dyspnea; higher incidence of lymphopenia; and lower incidence of elevated serum C‐reactive protein. Among the 227 patients with radiographs available, lung involvement was found in 19 (8·4%) (52·6% consolidation and 47·4% interstitial infiltrations), including 18 children and one adult. One child with lung consolidation died of multiorgan failure. Significant findings in patients with lung involvement included predominant young age (≤10 years), prolonged fever, and delayed oseltamivir therapy (≥48 hours after onset of illness); higher frequencies of dyspnea, nausea/vomiting, and altered consciousness; and higher incidences of leukopenia, elevated serum creative kinase, and lactic dehydrogenase. Conclusions Among patients with 2009 pandemic influenza A (H1N1), we found significant difference in clinical manifestations between children and adults, and significant differences in clinical and laboratory manifestations between patients with lung involvement and those without. On the basis of data from this study and the existing literature, early treatment with oseltamivir is recommended for patients with 2009 pandemic influenza A (H1N1), regardless of age.

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“…This rate is higher than that previously reported from pandemic studies in the United States and Cyprus (6 and 17% respectively) [7,8]. A higher rate (52%) of hospitalization of infants with Influenza A(H1N1)pdm09 has been reported from Argentina [4]. Table 1.…”

Section: Discussionmentioning

confidence: 56%

Hospitalization patterns and outcomes of infants with Influenza A(H1N1) in Kuwait

Husain

Al-Khabaz

Al-Qattan

et al. 2012

J Infect Dev Ctries

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Introduction: Infants represent an important risk group for influenza associated hospitalizations and mortality. This study evaluated the clinical presentations, hospitalization course and outcome of infants hospitalized with the pandemic influenza A H1N1 [Influenza A(H1N1)pdm09] in relation to their previous health status. Methodology: We conducted a retrospective chart review of hospitalized infants with laboratory-confirmed Influenza A(H1N1)pdm09 infection in two hospitals in Kuwait. Demographic characteristics, pre-existing high-risk medical conditions, clinical presentations, complications and mortality were analyzed. Previously healthy infants' data were compared with infants with pre-existing high-risk medical conditions for severity of the illness and outcome. Results: We identified 62 infants comprising 32% of all admissions with Influenza A(H1N1)pdm09. The median age  SD was 7  4 months. Nineteen (31%) had pre-existing high-risk medical conditions. Complications were documented in 53% of previously healthy infants compared to 47% in high-risk infants. Mean duration of hospitalization was 4.9 days in healthy infants and 6.7 for infants with highrisk medical conditions. Bacterial pneumonia complicated 7% of previously healthy infants compared to 26% with high-risk conditions (P = 0.03). Four infants (6.5%) required admission to the intensive care unit (ICU), of whom three had high risk medical condition. Conclusion: The majority of hospitalized infants with Influenza A(H1N1)pdm09 were previously healthy. Prolonged hospitalization, ICU admission and mortality were more observed in infants with high-risk medical conditions. According to the latest Advisory Committee on Immunization Practices (ACIP) recommendations, annual influenza vaccination is recommended for any child six months of age and older, particularly those with risk factors.

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Pediatric Hospitalizations Associated with 2009 Pandemic Influenza A (H1N1) in Argentina

Abstract: Pandemic 2009 H1N1 influenza was associated with pediatric death rates that were 10 times the rates for seasonal influenza in previous years.

Cited by 348 publications

References 18 publications

Viral epidemiology of respiratory infections among children at a tertiary hospital in Southern Brazil

Viral epidemiology of respiratory infections among children at a tertiary hospital in Southern Brazil

2009 pandemic Influenza A (H1N1): clinical and laboratory characteristics in pediatric and adult patients and in patients with pulmonary involvement

Hospitalization patterns and outcomes of infants with Influenza A(H1N1) in Kuwait

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