Pediatric En Bloc Kidney Transplantation to Adult Recipients: More Than Suboptimal?

Bhayana, Suverta; Kuo, Yong Fang; Madan, Pankaj; Mandaym, Sreedhar; Thomas, Philip; Lappin, Jacqueline; Rice, James; Ishihara, Kanae

doi:10.1097/tp.0b013e3181e641f8

Cited by 59 publications

(74 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…While early reports of increased vascular complications with en bloc transplantation were discouraging [14][15][16][17], recent reports have shown more encouraging outcomes [4,[18][19][20], further confirmed by our study findings. This is likely due to increased experience and improvements in surgical techniques over time, which should help further reduce the skepticism in using young donor kidneys for transplantation.…”

Section: Other Benefits Of En Bloc Transplantssupporting

confidence: 81%

Update on En Bloc Renal Transplantation in Pediatric Recipients

Butani¹

2017

J Nephrol Ther

View full text Add to dashboard Cite

Section: Other Benefits Of En Bloc Transplantssupporting

confidence: 81%

Update on En Bloc Renal Transplantation in Pediatric Recipients

Butani¹

2017

J Nephrol Ther

View full text Add to dashboard Cite

“…[4][5][6] Multiple studies have demonstrated that en bloc kidney transplants from pediatric donors to both adult and pediatric recipients have good clinical outcomes, including long-term graft survival and reduced rates of delayed graft function. [7][8][9][10][11] Recent studies have shown good clinical outcomes with very small pediatric donors. 6,12 Successful en bloc kidney transplantation from newborn and infant donors into both adult and pediatric recipients has recently been reported.…”

mentioning

confidence: 99%

Identifying Potential Kidney Donors Among Newborns Undergoing Circulatory Determination of Death

Hanley¹,

Kim

Willey

et al. 2014

Pediatrics

View full text Add to dashboard Cite

BACKGROUND: Over 96 000 patients await kidney transplantation in the United States, and 35 000 more are wait-listed annually. The demand for donor kidneys far outweighs supply, resulting in significant waiting list morbidity and mortality. We sought to identify potential kidney donors among newborns because en bloc kidney transplantation donation after circulatory determination of death (DCDD) may broaden the donor pool. METHODS: We reviewed discharges from our 84-bed NICU between November 2002 and October 2012 and identified all deaths. The mode of death among potential organ donors (weight ≥1.8 kg) was recorded. Patients undergoing withdrawal of life support were further evaluated for DCDD potential. After excluding patients with medical contraindications, those with warm ischemic time (WIT) less than 120 minutes were characterized as potential kidney donors. RESULTS: There were 11 201 discharges. Of 609 deaths, 359 patients weighed ≥1.8 kg and 159 died after planned withdrawal of life support. The exact time of withdrawal could not be determined for 2 patients, and 100 had at least 1 exclusion criterion. Of the remaining patients, 42 to 57 infants were potential en bloc kidney donors depending on acceptance threshold for WIT. Applying a 40% to 70% consent rate range would yield 1.7 to 4 newborn DCDD donors per year. CONCLUSIONS: A neonatal DCDD kidney program at our institution could provide 2 to 4 paired kidneys for en bloc transplantation each year. Implementing a DCDD kidney donation program in NICUs could add a new source of donors and increase the number of kidneys available for transplantation.

show abstract

“…While early reports of increased vascular complications with en bloc transplantation were discouraging [27][28][29][30], recent reports have shown more encouraging outcomes [5,11,26,31]. This is likely due to increased experience and improvements in surgical techniques over time, which should help further reduce the skepticism in using young donors for transplantation.…”

Section: Advantages Of En Bloc Over Solitary Grafts From Young or Idementioning

confidence: 95%

“…The graft survival of en bloc kidneys has been at least comparable to standard deceased donor kidneys [4,[8][9][10][11][12]. Some studies in fact have shown superior outcomes with en bloc transplants compared to standard deceased donor and even live donor transplants [13][14][15].…”

Section: En Bloc Renal Transplantation Is a Viable And Safe Option Tomentioning

confidence: 99%

Expanding the Organ Donor Pool: Using En Bloc Kidneys in Pediatric Recipients

Lau¹,

Butani²

2012

J Nephrol Therapeut

View full text Add to dashboard Cite

Pediatric En Bloc Kidney Transplantation to Adult Recipients: More Than Suboptimal?

Abstract: EBK had the best long-term outcomes among deceased donor transplants and offer unique options for adult kidney transplant recipients.

Cited by 59 publications

References 51 publications

Update on En Bloc Renal Transplantation in Pediatric Recipients

Update on En Bloc Renal Transplantation in Pediatric Recipients

Identifying Potential Kidney Donors Among Newborns Undergoing Circulatory Determination of Death

Expanding the Organ Donor Pool: Using En Bloc Kidneys in Pediatric Recipients

Contact Info

Product

Resources

About