Pediatric basal cell carcinoma: case reports and literature review

Efron, Philip A.; Chen, Mike K.; Glavin, Frederick L.; Kays, David W.; Beierle, Elizabeth A.

doi:10.1016/j.jpedsurg.2008.08.035

Cited by 29 publications

(30 citation statements)

References 18 publications

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“…Multiple BCCs in a teenager should alert physicians to the possibility of a genetic syndrome. This should be followed by careful physical examination that includes the search for other symptoms and signs (Efron et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

Case Report Multiple nevoid basal cell carcinoma syndrome associated with congenital orbital teratoma, caused by a PTCH1 frameshift mutation

Rodrigues¹,

Carvalho²,

Cabral³

et al. 2014

Genet. Mol. Res.

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Section: Discussionmentioning

confidence: 99%

Case Report Multiple nevoid basal cell carcinoma syndrome associated with congenital orbital teratoma, caused by a PTCH1 frameshift mutation

Rodrigues¹,

Carvalho²,

Cabral³

et al. 2014

Genet. Mol. Res.

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“…37,44,45 Still, a higher proportion of young women have been diagnosed with BCC, which may be associated, in addition to the above factors, with natural and artificial tanning in the last decades. 30,37,[46][47][48][49] The relationship between patterns of sun exposure, age of onset and histological aggressiveness of BCC is controversial among researchers; therefore, more epidemiological studies involving different population groups need to be conducted in an attempt to elucidate this matter. 50.51 The most important constitutional risk factors for the development of BCC are: light phototypes (I and II by Fitzpatrick classification), positive family history of BCC (30-60%), freckles in childhood, light skin, eyes or hair.…”

Section: To 38mentioning

confidence: 99%

Epidemiologia do carcinoma basocelular

Chinem

Miot

2011

An. Bras. Dermatol.

122

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Basal cell carcinoma is the most common malignant neoplasm in humans and its incidence has increased over the last decades. Its high frequency significantly burdens the health system, making the disease a public health issue. Despite the low mortality rates and the rare occurrence of metastases, the tumor may be locally invasive and relapse after treatment, causing significant morbidity. Exposure to ultraviolet radiation is the main environmental risk factor associated with its cause. However, other elements of risk are described, such as light skin phototypes, advanced age, family history of skin carcinoma, light eyes and blond hair, freckles in childhood and immunosuppression. Behavioral aspects such as occupational sun exposure, rural labor and sunburns at a young age also play a role. Between 30% and 75% of the sporadic cases are associated with patched hedgehog gene mutation, but other genetic changes are also described. The tumor is commonly found in concomitance with skin lesions related to chronic sun exposure, such as actinic keratoses, solar lentigines and facial telangiectasia. The prevention of basal cell carcinoma is based on the knowledge of risk factors, early diagnosis and treatment, as well as on the adoption of specific measures, particularly in susceptible populations. The authors present a review of the epidemiology of basal cell carcinoma. Keywords: Injections, intradermal; Review; Skin; Therapeutics Resumo: O carcinoma basocelular é a neoplasia maligna mais comum em humanos e sua incidência vem aumentando nas últimas décadas. Sua grande frequência gera significativo ônus ao sistema de saúde, configurando problema de saúde pública. Apesar das baixas taxas de mortalidade e de rara ocorrência de metástases, o tumor pode apresentar comportamento invasivo local e recidivas após o tratamento, provocando importante morbidade. Exposição à radiação ultravioleta representa o principal fator de risco ambiental associado a sua gênese. Entretanto, descrevem-se outros elementos de risco: fotótipos claros, idade avançada, história familiar de carcinomas de pele, olhos e cabelos claros, sardas na infância e imunossupressão, além de aspectos comportamentais, como exercício profissional exposto ao sol, atividade rural e queimaduras solares na juventude. Entre 30% e 75% dos casos esporádicos estão associados à mutação do gene patched hedgehog, mas outras alterações genéticas são ainda descritas. A neoplasia é comumente encontrada concomitantemente com lesões cutâneas relacionadas à exposição solar crônica, tais como: queratoses actínicas, lentigos solares e telangiectasias faciais. A prevenção do carcinoma basocelular se baseia no conhecimento de fatores de risco, no diagnóstico e tratamento precoces e na adoção de medidas específicas, principalmente, nas populações susceptíveis. Os autores apresentam uma revisão da epidemiologia do carcinoma basocelular.

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“…It usually arises in the sun‐exposed areas of the body. A variety of factors have been reported to play an important role in the aetiology of BCC, including cumulative exposure to UV‐radiation, radiotherapy, immunosuppression, Fitzpatrick skin type 1 and 2, a positive family history and genetic defects 18 …”

Section: Discussionmentioning

confidence: 99%