The cations in ferrites with spinel structure of the Me Fe (hlexFe2-x)04 type 1-x x (Me two-valent cations, x degree of inversion) may occupy two different types of sitesthe tetrahedral (a) and the octahedral ones (b), formed by the close packing of oxygen anions. It i s well-known (1, 2) that the equilibrium cation distribution at a temperature T i s determined by the mass action law) change of the internal energy of a where k Boltzmann constant, E b ferrite molecule connected with the cation pair exchange, E. preference energy of cations of type i (i: Me, Fe) to the site b. b = Enile -EFe 0 1 From equation (1) it follows that the immediate determination of E from meas-0 urements of the temperature dependence of the degree of inversion o r from different properties, caused by the degree of inversion, is possible only for ferrites with low values of E b i (for example, Me = Mg , Cu) .In this paper a method of experimental determination of high values of the preference energy is proposed with zinc ferrite a s an example (it possesses the structure of the normal spinel under the usual conditions). The essence of the method is the following.-2By irradiation with fast neutrons of D ,lo2' cm dose on ferrites an irreversible non-equilibrium cation distribution i s achieved at T = 320 K close to the statistical one x = 2/3 (3). This is accompanied by an increase of the ferrite internal energy with a value proportional to E . During the annealing this stored energy transfers into the specimen thermal energy and it allows to determine E . 0 0