Peculiarities of Morphogenesis of Universal Hematopoesis and Immune Protection in Fetuses of Domestic Pig

Gavrilin, P. M.; Agrarian, Dnipropetrovsk State; Oliyar, A. V.; Myrnyi, O.

doi:10.15407/animbiol18.04.030

Cited by 3 publications

(4 citation statements)

References 5 publications

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“…Абсолютна маса скелета зростає періодично, з максимальними значеннями наприкінці першої половини та протягом другої половини плідного періо-ду онтогенезу. У різних відділах скелету поросят абсолютна маса змінюється асинхронно, тенденція зростання маси кісток осьового скелету має випереджаючий характер, а кісток скелету кінцівок, навпаки, тенденцію до зниження (Myrnyi & Oliyar, 2014;Gavrilin et al, 2016;Myrnyi, 2017). У жуйних ссавців усі основні та додаткові осередки окостеніння формуються в пренатальному періоді онтогенезу і теж мають свої особливості.…”

Section: обговоренняunclassified

“…Нашими дослідженнями встановлено, що в новонароджених поросят досліджувані кістки (стегнова кістка і 9-й грудний хребець) скелету мають мінімальні морфометричні параметри, що узгоджується з даними інших дослідників (Gavrilin & Nykyforenko, 2005;Evert et al, 2018).…”

Section: обговоренняunclassified

“…Ріст і розвиток кісткового мозку прямо залежить від процесів енхондрального остеогістогенезу, в процесі якого разом з формуванням губчастої кісткової тканини, безпосереднім місцем його локалізації утворюється специфічне тканинно-клітинне мікрооточення (Gavrilin & Nykyforenko, 2005).…”

Section: обговоренняunclassified

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Structural and functional organization of central organs of hematopoiesis and immune protection of piglets during the early postnatal period of ontogenesis

Oliiar¹,

Lieshchova²

2019

TAVM

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Factors of the environment and anthropogenic factors have an negatively influence on the body of newnate animals, especially with unfinished morphofunctional status, which often leads to a decrease in the resistance and development of immunodeficient conditions. The thigh bone, 9th thoracic vertebra and thymus of piglets were studied during the early postnatal ontogenesis (1-, 5-, 10-, 15-day-old age) of Ukrainian white breed, which was reared in accordance with traditional technologies. The dynamics of absolute, relative mass of organs, relative area of tissue components and centers of ossification of bones were determined by means of histologic, X-ray and morphometric methods. It has been established that in neonates and piglets of the neonatal period, the morphofunctional status of blood formation and immune protection central organs is determined by the ratio of parenchymal and stromal tissue components, which affects the realization of adaptive capabilities and viability of animals. In the thigh bone of the newborn piglets, all main and secondary ossification cells are developed, and in the 9th thoracic vertebra only diaphyseal. The bone marrow is clearly differentiated into osteoblastic, red and yellow; the degree of development, the peculiarities of localization and structure of each of them are determined by the morphofunctional status of components of microenvironment-bone and cartilaginous tissues. The bone tissue is divided into primary tissue, which is located in the zones of bone growth and is filled with osteoblastic bone marrow, and the secondary spongy bone, which is localized in epiphyses and diaphyses with red bone marrow, fat cells, and also compact bone. The peculiarity of the tissue organization of the thymus is the development of connective tissue and a special reticuloepithelial stroma, as well as the differentiation of lymphoid tissue on the cortical and brain areas with a clear boundary and the presence of the brain layered epithelial cells (the presence of Hassall's corpuscles (thymic corpuscles bodies) in the brain. In piglets of the neonatal period, in the organs of universal hemopoiesis, the number of red and yellow bone marrow, as well as bone tissue increases, and while-osteoblastic bone marrow and cartilage tissue decreases. In the central organ of lymphocytopoiesis, the thymus, the increase of lymphoid tissue occurs.

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Section: обговоренняunclassified

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Structural and functional organization of central organs of hematopoiesis and immune protection of piglets during the early postnatal period of ontogenesis

Oliiar¹,

Lieshchova²

2019

TAVM

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“…У науковій літературі вкрай мало інформації про особливості структурно-функціональної організації, цито-та гістогенез кровотворних компонентів скелета у продуктивних тварин, і вони обмежені даними, що в добових та молодих тварин кістковий мозок є червоним, який з віком заміщується на жовтий, або жировий. Проте останнім часом у деяких роботах подано результати досліджень аспектів морфогенезу біомеханічних та кровотворних структур скелета у ссавців в пренатальному та ранньому постнатальному онтогенезі (Krishtoforova et al, 2002;Sokolov, 2004;Nykyforenko, 2008;Havrylin and Sosonyi, 2010;Snetkova, 2010;Gavrilin et al, 2016).…”

Section: вступunclassified

Структурно-Функціональна Організація Кісткового Мозку Поросят

Gavrilin¹,

Lieshchova²,

Evert³

et al. 2017

SMLNUVMB

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The aim of the study was to establish the degree of the development of the bone marrow and activity of its hematopoietic function by the morphometric parameters of the bones, where it is localized, and the centers of ossification in conjunction with the development of cartilage and bone tissue, define the features of the histo- and cytoarchitectonics of the hematopoietic components in the centers of the bone ossification in piglets. It is submitted, the results of the complex researching of the structural and functional features in the osseous organs (5th thoracal vertebra, 5th costal bone, sternum) in the 60- days age piglets due to their hematopoietic function. The absolute, relative mass, bone density, availability and relative area of their centers of the ossification, the relative area of bone marrow, cartilage and bone tissue in the centers of ossification and the relative area of bone marrow cells (osteogenic, hematopoietic and adipocytes) and the cell stroma (reticular and endothelial cells , macrophages, fibroblasts) in the zones of primary and secondary spongy osteine was determined. It is established that the red bone marrow is an integral component of the centers of the ossificaton, hematopoietic and osteogenic structure of which, together with the components of the hemopoietic microsurrounding, histogenetic topographically closely interrelated. The development of the bone marrow hematopoietic components in the bones of the axial skeleton in the 60-days age piglets expresses with the scale of the enchondral osteohistogenesis. The morphometric characteristics of the ossification centers, the relative quantity of the cells in the bone marrow and osteine, the presence of a multicomponent system of the hemopoietic microsurrounding and expressed zonal structure of spongy bone substance are the main criteria of the degree of development of the bone marrow and, therefore, of the potential blood-forming. It is found that bone marrow cells in the ossification centers of the axial skeleton in the 60-days age pigs characterized by expressed heterogeneous structure and in the primary areas of spongy osteine it has hematopoietic-osteogenic form, in the areas of secondary spongy osteine – insular or diffuse insular hematopoietic form with the presence of the individual adipocytes, the quantity of which increases towards the central zone of the ossification centers. In the areas of the growth, the main cells` population on the periphery of the centers of ossification are the osteoblast cells. In the centers of the secondary spongy osteine, hematopoietic cells are dominated, the largest «concentration» of their are characteristic for the centers sites with a maximum degree development of morphological features of the osteohistogenesis and remodulation of the bone tissue.

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Morphogenesis of the centers of ossiﬁ cation of bone organs of piglets in the early postnatal period of ontogenesis

Oliyar

Lieshchova

Logvinova

2020

Nauk. vìsn. vet. med.

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The dynamics of growth and development of the basic and additional centers of ossiﬁ cation of bone organs gives an opportunity to ﬁ nd out the patterns of change of their tissue components and subsequent age-related remodeling when performing biomechanical and hematopoietic functions. Features of morphogenesis of hematopoietic components of the skeleton in productive animals should be taken into account in determining the etiopathogenesis and development of methods of treatment and prevention of infectious diseases, immunodeﬁ ciency and anemic conditions in young animals. Were studied bone organs (9th thoracic vertebra, femur) from clinically healthy newborns, 5-, 10-, 15- and 20-day-old pigs (n = 5) of white Ukrainian breed grown using traditional technologies. Radiological research in the organs of universal hematopoiesis determined the availability and degree of development of the dia-, epi- and apophysar centers of ossiﬁ cation, as well as features of the structure of spongy and compact bone tissue. Determination of the relative area of the centers of ossiﬁ cation on radiograph was performed by the method of “point counting” using the eyepiece test systems according to the method of G.G. Avtandilova. In newborn piglets, the bones of the axial skeleton show only the diaphysar (body) centers of ossiﬁ cation and brackets, whereas in the bones of the peripheral bone, the diaphysar and epiphysar ones, as well as the apophysar (larger swivel). With age, the number of limb bones does not change, and the axial skeleton, except for previously formed diaphysar and brackets, appear epiphysar (heads and fossae), starting at the age of 20 days. In all bones there is an increase in the size and relative area of previously formed centers of ossiﬁ cation. In bone organs of all age groups, small-cell spongy bone prevails, whereas compact at the moment of birth, it is present only in the peripheral skeleton, and in axial - it ﬁ rst appears in the body of a vertebra of 10-day piglets and also in the brackets - 20-day piglets. The thickness of metaphysar cartilages, subchondral bones of articular cartilages, as well as the epi- and diametaphysar subchondral bones increases with age. Key words: blood forming and immune protection organs, skeleton, bone organs, basic and additional centers of ossiﬁ cation, bone tissue, piglets.

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Peculiarities of Morphogenesis of Universal Hematopoesis and Immune Protection in Fetuses of Domestic Pig

Cited by 3 publications

References 5 publications

Structural and functional organization of central organs of hematopoiesis and immune protection of piglets during the early postnatal period of ontogenesis

Structural and functional organization of central organs of hematopoiesis and immune protection of piglets during the early postnatal period of ontogenesis

Структурно-Функціональна Організація Кісткового Мозку Поросят

Morphogenesis of the centers of ossiﬁ cation of bone organs of piglets in the early postnatal period of ontogenesis

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