Peculiarities of microweighing of trace quantities of alkylamines on polymer and solid-state thin films

Кучменко, Т. А.; Умарханов, Р. У.

doi:10.1134/s1061934813040059

Cited by 9 publications

(4 citation statements)

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“…The choice of sensors for an array is influenced by their high sensitivity to various classes of volatile substances, including volatile biomarkers of diseases in the urine [ 14 , 15 , 16 ]. Films of 18C6, Tween were chosen for the detection of carboxylic and hydroxy acids [ 47 , 48 ], and MCNT, BCB, MR for ammonia and amines [ 49 , 50 , 51 ]. PEGSb was selected for detection of acids, alcohols, ketones [ 52 , 53 ], and TX-100 for nitrogen- and sulfur-containing compounds [ 54 , 55 ].…”

Section: Methodsmentioning

confidence: 99%

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Noninvasive Detection of Bacterial Infection in Children Using Piezoelectric E-Nose

Кучменко

Menzhulina

Шуба

2022

Sensors

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Currently, antibiotics are often prescribed to children without reason due to the inability to quickly establish the presence of a bacterial etiology of the disease. One way to obtain additional diagnostic information quickly is to study the volatile metabolome of biosamples using arrays of sensors. The goal of this work was to assess the possibility of using an array of chemical sensors with various sensitive coatings to determine the presence of a bacterial infection in children by analyzing the equilibrium gas phase (EGP) of urine samples. The EGP of 90 urine samples from children with and without a bacterial infection (urinary tract infection, soft tissue infection) was studied on the “MAG-8” device with seven piezoelectric sensors in a hospital. General urine analysis with sediment microscopy was performed using a Uriscan Pro analyzer and using an Olympus CX31 microscope. After surgical removal of the source of inflammation, the microbiological studies of the biomaterial were performed to determine the presence and type of the pathogen. The most informative output data of an array of sensors have been established for diagnosing bacterial pathology. Regression models were built to predict the presence of a bacterial infection in children with an error of no more than 15%. An indicator of infection is proposed to predict the presence of a bacterial infection in children with a high sensitivity of 96%.

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Section: Methodsmentioning

confidence: 99%

“…Therefore, the resulting array should be effective for solving the problem. The mass sensitivities of selected sensors to some VOC vapors, which were obtained in earlier studies [ 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 ], are presented in Table 2 .…”

Section: Methodsmentioning

confidence: 99%

Noninvasive Detection of Bacterial Infection in Children Using Piezoelectric E-Nose

Кучменко

Menzhulina

Шуба

2022

Sensors

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“…The sensors were chosen to make an array based on their high sensitivity to various classes of volatile substances, including the biomarkers of diseases in urine [ 7 – 12 ]: DCH18C6 and Tween-40 films were chosen for the detection of carboxylic and hydroxy acids [ 24 , 25 ]; MWCNTs, BCB, and MR were used for ammonia and structurally different amines [ 26 – 28 ]; PEGSb was used for ketones and organic acids [ 24 , 29 , 30 ]; and TX-100 was used for nitrogen- and sulfur-containing compounds [ 30 , 31 ]. Moreover, the selected films were stable for at least a year in the analysis of small amounts of volatile substances [ 22 ] contained in biosamples.…”

Section: Methodsmentioning

confidence: 99%

On a Correlation between the Results of In-Hospital Analysis of Biosamples from Children Performed Using Standard Methods and an Array of Piezosensors

et al. 2022

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A rapid procedure for obtaining information on changes in particular characteristics of urine as the most frequently taken biosample is presented. The relationship between the output data of an array of piezoelectric sensors based on different micro- and nanostructured phases and the standard characteristics of clinical urine analysis is discussed. Volatile organic compounds identified in an equilibrium headspace gas phase of the samples with deviations from normal characteristics of clinical urine analysis are considered. The tetrachoric correlation coefficients and associations between the parameters of a sensor array and standard characteristics were calculated. A minimum set of calculated parameters of an electronic nose for the rapid in-hospital monitoring of changes in the patient’s condition in the course of therapy or medical examination was recognized. A fast and economically affordable method was developed for the monitoring of body state characteristics using the profile of volatile urine compounds obtained with an electronic nose based on piezosensors. Two versions, a color scale and a table, were proposed for presenting the electronic nose data; they can be used even by specially untrained personnel for the rapid and easy assessment of the most important urine analysis data (protein, glucose, mucus, and bacteria). The method developed makes it possible to quickly (the time of a measurement is 120 s) perform the daily monitoring of patient’s condition to avoid an unnecessary burden on the laboratory and to increase the physician’s awareness of the dynamics of the patient’s condition and facilitate the choice of treatment tactics. This method can be used for clinical examinations in polyclinics and feldsher’s stations, and it will significantly shorten the time taken to obtain screening and diagnostic information on disruptions in the body, in particular, at the initial stages of diseases.

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“…High mass sensitivity and fast response times in a piezoelectric resonator allow for active applications of piezoquartz microweighing in different fields [1]. Thus, a lot of attention is devoted to the selective detection of several species in air, among them carbon and nitrogen oxides [65], formaldehyde, ammonia [58,66], VOC-arenes [52,58,62], alcohols, ketones [50,58,66], amines [67,68], pesticides [69,70], short-chain aliphatic acids [59,71], etc. Moreover, often it is important to detect these compounds in a sample separately, since most of them belong to marker substances for assessing either environmental safety (nitrogen oxides, formaldehyde, arenas, pesticides) or the state of living objects (alcohols, ketones, amines, ammonia, acids (for all types of bioassays and food systems).…”

Section: Single Piezosensor Applicationsmentioning

confidence: 99%

A Perspective on Recent Advances in Piezoelectric Chemical Sensors for Environmental Monitoring and Foodstuffs Analysis

Кучменко

Lvova

2019

Chemosensors

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This paper provides a selection of the last two decades publications on the development and application of chemical sensors based on piezoelectric quartz resonators for a wide range of analytical tasks. Most of the attention is devoted to an analysis of gas and liquid media and to industrial processes controls utilizing single quartz crystal microbalance (QCM) sensors, bulk acoustic wave (BAW) sensors, and their arrays in e-nose systems. The unique opportunity to estimate several heavy metals in natural and wastewater samples from the output of a QCM sensor array highly sensitive to changes in metal ion activity in water vapor is shown. The high potential of QCM multisensor systems for fast and cost-effective water contamination assessments “in situ” without sample pretreatment is demonstrated.

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Peculiarities of microweighing of trace quantities of alkylamines on polymer and solid-state thin films

Cited by 9 publications

References 0 publications

Noninvasive Detection of Bacterial Infection in Children Using Piezoelectric E-Nose

Noninvasive Detection of Bacterial Infection in Children Using Piezoelectric E-Nose

On a Correlation between the Results of In-Hospital Analysis of Biosamples from Children Performed Using Standard Methods and an Array of Piezosensors

A Perspective on Recent Advances in Piezoelectric Chemical Sensors for Environmental Monitoring and Foodstuffs Analysis

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