Peanuts improve blood glutathione, HDL-cholesterol level and change tissue factor activity in rats fed a high-cholesterol diet

Emekli-Alturfan, Ebru; Kasikci, Emel; Yarat, Ayşen

doi:10.1007/s00394-007-0688-1

Cited by 20 publications

(15 citation statements)

References 35 publications

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“…Besides blood, various tissues and body fluids (saliva, amniotic fluid, bile, semen, sweat or tears) have been known to have TF activity [20][21][22][23][24][25] . Most of them are not easily obtained; thus, saliva is especially suitable for study because of its ready availability.…”

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confidence: 99%

Plasma Tissue Factor Levels and Salivary Tissue Factor Activities of Periodontitis Patients with and without Cardiovascular Disease

Emekli-Alturfan¹,

Başar

Malali

et al. 2010

Pathophysiol Haemos Thromb

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The association between periodontal and cardiovascular disease has received considerable attention. Studies have demonstrated a higher incidence of atherosclerotic complications in patients with periodontal disease. Tissue factor (TF) has been known as a key initiator of the coagulation cascade, and the TF pathway is the primary physiological mechanism of initiation of blood coagulation. Recently, it has been shown that the circulating pool of TF in blood is associated with increased blood thrombogenicity in patients with coronary artery disease (CAD). Various tissues and saliva have been known to have TF activity. Consequently, the aim of this study was to investigate plasma TF levels and TF activity of saliva in periodontitis patients with and without diagnosed CAD. Twenty-six patients with a diagnosis of CAD and 26 systemically healthy patients were examined in the dental clinic, and the Community Periodontal Index Treatment Needs (CPITN) scores were recorded. Plasma TF levels were determined using commercially available ELISA kit. Salivary TF activities were determined according to Quick’s one-stage method. Plasma TF levels were significantly increased in patients with CAD when compared with the control group. There was no difference in salivary TF activities between the 2 groups, but there was a strong and negative correlation between salivary TF activities and CPITN indexes in both groups. In order to determine the possible role of TF activity as a salivary marker in CAD and periodontitis and to fully understand the negative correlation between salivary TF activities and CPITN, TF activity of gingival crevicular fluid that may also affect saliva can be evaluated.

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confidence: 99%

Plasma Tissue Factor Levels and Salivary Tissue Factor Activities of Periodontitis Patients with and without Cardiovascular Disease

Emekli-Alturfan¹,

Başar

Malali

et al. 2010

Pathophysiol Haemos Thromb

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“…Again, some investigators observed that peanut consumption significantly improve the antioxidant-oxidant status by increasing glutathione peroxidase (GSH) and decreasing thiobarbituric acid reactive substance (TBARS) levels 24 . High level of L-arginin and vitamine E content of peanut also have antioxidant activity and scavange oxygen free radicals thereby preserve normal histological architecture of heart 25 .…”

Section: Discussionmentioning

confidence: 99%

Protective Effect of Peanut (Arachis hypogaea L.) and Its Combination with Propranolol in Cardiotoxic Rats

Naz

Jahan

Sultana³

2015

J Bangladesh Soc Physiol

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Background: Cardiotoxicity (CT) can be developed due to prolonged use of higher doses of some drugs, exposure to some chemicals, toxins or infectious agents and also by some disease conditions. Natural plant foods such as peanut (Arachis hypogaea L.) may have free radical scavenging activity, thereby can be used for the prevention and management of heart disease. Objective: To observe the protective effect of peanut (Arachis hypogaea L.) and its combined action with propranolol on histological changes in isoproterenol induced cardiotoxic rats. Method: This experimental study was carried out in the Department of Physiology, Sir Salimullah Medical College, Dhaka in 2012. For this purpose, 20 Wistar albino rats, age 85-100 days, weighing 120 to 150g (initial body weight) were included in the peanut treated group. They were sub-divided into CT-ISO-P (Cardiotoxic group with isoproterenol after peanut treatment) and CT-ISO-C (Cardiotoxic group with isoproterenol after combined treatment of peanut and propranolol). Age and weight matched 30 Wistar albino rats without any peanut supplementation were taken and sub-divided into three sub-groups, BC (Baseline control), CT-ISO (Cardiotoxic group with isoproterenol) and CT-ISO-PRO (Cardiotoxic group with isoproterenol after propranolol treatment). Each sub-group consisted of 10 rats. After taking final body weight all the rats were sacrificed on 22 nd day. The heart was removed and preserved in 10% formalin for histological processing. To find out the histopathological changes of heart tissue, histological slides were prepared and were observed under microscope in the Department of Pathology, SSMC. Histological findings were categorized by scoring as mild, moderate and severe histological changes. The statistical analysis was done by one way ANOVA and Bonferroni test as applicable. Result: In this study, percent change from initial body weight to final body weight was significantly (p<0.01) lower both in CT-ISO-P and CT-ISO-C as compared to that of BC. Again, histological score was significantly (p<0.01) higher in CT-ISO in comparison to that of BC. Moreover, these scores were significantly lower in CT-ISO-PRO (p<0.01), CT-ISO-P (p<0.05) and CT-ISO-C (p<0.05) in comparison to that of CT-ISO. Similarly, this score was significantly (p<0.01) lower in CT-ISO-C when compared to that of CT-ISO-P. Conclusion: The present study revealed that peanut can preserve almost normal histological architecture of heart tissue in isoproterenol induced cardiotoxic rats. However, the combined therapy of peanut with propranolol showed synergistic effect on preventing histological changes in heart tissue.

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“…Similarly to chickpea, phenolics from peanut seeds and particularly peanut skin have high antifungal and antioxidative activity [13][14][15]. Positive effect of peanut on human health can be confirmed by the studies of Emekli-Alturfan et al [16], who ascertained that addition of peanut to the diet did not significantly change blood lipids, protrombin time, activated partial thromboplastin time, or fibrinogen levels, both in control and in hyperlipidemic groups. Peanut consumption improved glutathione (GSH) and high-density lipoprotein (HDL-C) levels and decreased thiobarbituric acid reactive substances (TBARS), without increasing other blood lipids in experimental hyperlipidemia.…”

Section: Introductionmentioning

confidence: 92%

Variations in level of oil, protein, and some antioxidants in chickpea and peanut seeds

Dragičević

Kratovalieva

Dumanović

et al. 2015

Chem. Biol. Technol. Agric.

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Background: Chickpea and peanut are two legume species not frequently used in human diets. Chickpea is rich in starch and proteins, while peanut is mainly a source of oils and proteins and they could be successfully used as protein sources in vegetarian diets. Seeds of 19 chickpea and 13 peanut landraces were colorimetrically analyzed in respect to antioxidant content (i.e., free soluble phenolics, total glutathione, and phytate). Oil and protein contents in grain were also determined. Results: Free soluble phenolics content varied in range from 520 to1,050 mg kg −1 in peanut and from 720 to 1,370 mg kg −1 in chickpea. Total glutathione content ranged from 1,495 to 2,365 mmol kg −1 in peanut and from 955 to 1,232 mmol kg −1 in chickpea. Relatively low content of phytic phosphorus was found in grain of both species, ranging from 2.5 to 4.5 g kg −1 in peanut and from 1.4 to 3.0 g kg −1 in chickpea, respectively. Considering the lack of data for phytate variability in Macedonian chickpea and peanut local landraces up to date, the observed high variation in phytic phosphorus content could represent the great basis for further breeding programs for phytate decrease in seeds of those genotypes. This is significant, since phytate is an important antinutrient which affects availability of mineral elements. Regression analysis revealed positive and highly significant interdependence between oil content and total glutathione in chickpea seeds, as well as between oil content and phytic phosphorus in peanut seeds. In chickpea, significant and negative correlation between oil and phytic phosphorus content was also observed. Conclusions: Results obtained indicated that chickpea genotypes with higher oil content could have increased nutritional value due to higher glutathione and lower phytate content observed. However, lower level of phytate content, along with higher level of soluble phenolics and total glutathione found in peanut seeds with lower oil content, indicated higher digestibility and increased antioxidant activity of those genotypes.

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Peanuts improve blood glutathione, HDL-cholesterol level and change tissue factor activity in rats fed a high-cholesterol diet

Abstract: Peanut consumption improved GSH and HDL-C levels and decreased TBARS, without increasing other blood lipids in experimental hyperlipidemia. Nevertheless the mechanism of the effect of peanut consumption on the TF activity of tissues remains to be determined.

Cited by 20 publications

References 35 publications

Plasma Tissue Factor Levels and Salivary Tissue Factor Activities of Periodontitis Patients with and without Cardiovascular Disease

Plasma Tissue Factor Levels and Salivary Tissue Factor Activities of Periodontitis Patients with and without Cardiovascular Disease

Protective Effect of Peanut (Arachis hypogaea L.) and Its Combination with Propranolol in Cardiotoxic Rats

Variations in level of oil, protein, and some antioxidants in chickpea and peanut seeds

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