Peak &OV0312;O2 correction for fat-free mass estimated by anthropometry and DEXA

Abstract

Discrepancies between ANTHRO and DEXA measurements of FFM depend on the magnitude of the estimate: differences are typically within 10 to 15%. Importantly, FFM-corrected peak VO2 values can vary according to the method chosen for body composition assessment, especially when allometry is used for peak VO2 correction. These results demonstrate that ANTHRO-DEXA differences in FFM estimation do have relevant practical consequences for the analysis of maximum aerobic capacity in nontrained humans.

Age-graded reductions in quadriceps muscle strength and peak aerobic capacity in COPD

“…About half of the patients were current smokers ( Table 1). LL-LMM, isokinetic quadriceps peak torque, and peak VO 2 were clearly reduced compared to published data from healthy elderly subjects 15,17,28 . At peak exercise, patients generally had little ventilatory reserve and rather high Borg symptom scores for dyspnea and fatigue (Table 2).…”

“…Moreover, quadriceps muscle strength was positively related to D L CO in patients with COPD 18 . Age-related reductions in LL-LMM have been reported in healthy women and men 17 . Hopkinson at al.…”

“…Patients with COPD have a reduced level of daily physical activity, which is present even in the earliest stages of the disease 40 . It is for this reason that it is not very surprising that quadriceps muscle strength and peak V O 2 in patients with COPD is very low compared to healthy subjects 8,17,30 and not unlike that in patients entering cardiac rehabilitation 29 . Accordingly, the majority of subjects with COPD in our study (98.8%) had a metabolic equivalent below 8, which is an identified risk factor of death from any cause 6 .…”

“…However, lean muscle mass is expected to decrease over time, in particular in the lower limbs 13 and it is a well-known determinant of quadriceps muscle strength and peak V O 2 in patients with COPD 14,15 . In addition, gender and gas transfer capacity of the lungs have both been shown to be determinants of lean muscle mass, quadriceps muscle strength, and peak V O 2 in COPD and should therefore also be taken into consideration 10,14,[16][17][18][19][20] .…”

Clinical Relevance of Inter-Method Differences in Fat-Free Mass Estimation in Chronic Obstructive Pulmonary Disease

“…We recently demonstrated that differences in FFM estimation by dual energy X-ray absorptiometry (DEXA) and ANTHRO were of practical importance in normal subjects [11]. In this particular study, the between-method discrepancies were sufficiently large to yield different exponents for the allometric correction of maximum aerobic capacity, i.e.…”