PDMS tri-block copolymers bearing quaternary ammonium salts for epidermal antimicrobial agents: Synthesis, surface adsorption and non-skin-penetration

Lei, Yufeng; Zhou, Shen; Dong, Chenyun; Zhang, Anqiang; Lin, Yaling

doi:10.1016/j.reactfunctpolym.2018.01.007

Cited by 30 publications

(27 citation statements)

References 30 publications

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“…for extraction of toxic metal ions from waste water [14], as chemical membrane sensors for Fe 3+ ions detection in water [15], as supports for metallic catalysts [16,17] or as stabilizers for metal nanoparticles [18]. After transformation into quaternary ammonium salts (QAS) they exhibit antimicrobial properties [19]. Similarly, polysiloxanes modified by other nitrogen-containing organic moieties, e.g.…”

Section: Introductionmentioning

confidence: 99%

“…Using cyclohexylamine-functionalized polymers, membranes on porous polyethylene supports were fabricated and applied for pervaporative enrichment of 1,3-propanediol from binary aqueous mixtures. Guerra-Contreras et al [33] and Lei et al [19] hydrosilylated N,N-dimethylallylamine (DMAA), i.e. a tertiary amine, with PHMS-DMS in the presence of Karstedt's catalyst (anhydrous toluene, 90-100 °C) which afforded amine-substituted polysiloxanes.…”

Section: Introductionmentioning

confidence: 99%

“…a tertiary amine, with PHMS-DMS in the presence of Karstedt's catalyst (anhydrous toluene, 90-100 °C) which afforded amine-substituted polysiloxanes. Then Lei et al [19] introduced PDMS blocks at both termini of the modified copolymer to obtain PDMS/amine-modified PHMS-DMS/PDMS triblock copolymer. In both studies, the synthesized polysiloxanes with amine groups were converted to the QAS by treatment with 1-iodooctane [33] or benzyl chloride [19].…”

Section: Introductionmentioning

confidence: 99%

“…Then Lei et al [19] introduced PDMS blocks at both termini of the modified copolymer to obtain PDMS/amine-modified PHMS-DMS/PDMS triblock copolymer. In both studies, the synthesized polysiloxanes with amine groups were converted to the QAS by treatment with 1-iodooctane [33] or benzyl chloride [19]. The prepared salts showed good solubility in polar organic solvents, such as ethanol [33] and high antibacterial activity [19].…”

Section: Introductionmentioning

confidence: 99%

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Functionalization of polyhydromethylsiloxane with nitrogen-containing organic compounds

et al. 2021

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Linear polyhydromethylsiloxane (PHMS) was functionalized with nitrogen-containing organic compounds: N-allylaniline (Naa), N-allylcyclohexylamine (Nach), N-allylpiperidine (Nap) and 4-vinylpyridine (4VP) via hydrosilylation reaction in the presence of Pt0 complex (Karstedt’s catalyst) under mild conditions. Reaction course was followed by FTIR spectroscopy and final hydrosilylation products were characterized by FTIR, 1H, 29Si NMR and 29Si MAS-NMR spectroscopies as well as by elemental analysis. Results showed that functionalization of PHMS with N-allyl amines took place but in none of the systems it was complete. Hydrosilylation of Naa, Nach and Nap with PHMS led both, to the β and α addition products. 29Si NMR spectroscopy showed unequivocally that the reaction of PHMS with 4VP did not occur and the only reactions in the systems were hydrolysis of Si–H groups of PHMS followed by condensation of the silanol groups resulting in cross-linking of the polymer. All the functionalized polymers studied in the work contained reactive amine moieties prone to further modifications, therefore exhibit a great potential for various applications.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Functionalization of polyhydromethylsiloxane with nitrogen-containing organic compounds

et al. 2021

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“…Also, these materials rapidly dissolve in the human body creating numerous clinical risks [2,3]. In spite of the desirable antibacterial properties, the traditional quaternary ammonium salts (QASs) and the antimicrobial peptides (AMPs) are highly toxic [4,5].…”

Section: Introductionmentioning

confidence: 99%

Gram-scale synthesis of splat-shaped Ag–TiO₂ nanocomposites for enhanced antimicrobial properties

Jaber¹,

Mushtaq²,

Zhang³

et al. 2020

Beilstein J. Nanotechnol.

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The control over contagious diseases caused by pathogenic organisms has become a serious health issue. The extensive usage of antibiotics has led to the development of multidrug-resistant bacterial strains. In this regard, metal-oxide-based antibacterial nanomaterials have received potential research interest due to the efficient prevention of microorganism growth. In this study, splat-shaped Ag–TiO2 nanocomposites (NCs) were synthesized on the gram scale and the enhanced antibacterial properties of TiO2 in the presence of silver were examined. The formation of Ag–TiO2 NCs was analyzed through various characterization techniques. The cell viability experimental results demonstrated that the Ag–TiO2 NCs have good biocompatibility. The antibacterial activity of the prepared Ag–TiO2 NCs was tested against the Gram-positive Staphylococcus aureus (S. aureus) and Gram-negative Escherichia coli (E. coli) bacterial strains. The Ag–TiO2 NCs exhibited promising and superior antibacterial properties compared to TiO2 nanospheres as confirmed by the bacterial growth and inhibition zone. The improvement in the antibacterial activity was attributed to the synergistic effect of the hybrid nature of TiO2 nanoparticles in the presence of Ag.

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Application of Spectroscopic Methods in the Studies of Polysiloxanes, Cubic Oligomeric Silsesquioxanes, and Spherosilicates Modified by Organic Functional Groups via Hydrosilylation

Chechelska-Noworyta

Mrówka

Owińska

et al. 2018

Challenges and Advances in Computational Chemistry and Physics

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PDMS tri-block copolymers bearing quaternary ammonium salts for epidermal antimicrobial agents: Synthesis, surface adsorption and non-skin-penetration

Cited by 30 publications

References 30 publications

Functionalization of polyhydromethylsiloxane with nitrogen-containing organic compounds

Functionalization of polyhydromethylsiloxane with nitrogen-containing organic compounds

Gram-scale synthesis of splat-shaped Ag–TiO₂ nanocomposites for enhanced antimicrobial properties

Application of Spectroscopic Methods in the Studies of Polysiloxanes, Cubic Oligomeric Silsesquioxanes, and Spherosilicates Modified by Organic Functional Groups via Hydrosilylation

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PDMS tri-block copolymers bearing quaternary ammonium salts for epidermal antimicrobial agents: Synthesis, surface adsorption and non-skin-penetration

Cited by 30 publications

References 30 publications

Functionalization of polyhydromethylsiloxane with nitrogen-containing organic compounds

Functionalization of polyhydromethylsiloxane with nitrogen-containing organic compounds

Gram-scale synthesis of splat-shaped Ag–TiO2 nanocomposites for enhanced antimicrobial properties

Application of Spectroscopic Methods in the Studies of Polysiloxanes, Cubic Oligomeric Silsesquioxanes, and Spherosilicates Modified by Organic Functional Groups via Hydrosilylation

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Gram-scale synthesis of splat-shaped Ag–TiO₂ nanocomposites for enhanced antimicrobial properties