volume 2, issue 8, PS425 2007
DOI: 10.1097/01.jto.0000283324.09033.b8
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Abstract: Background: This study was designed to evaluate the predictive role of mRNA quantification of three genes potentially related to platinum/ etoposide therapy in small-cell lung cancer (SCLC): ERCC1, RRM1 and TOPOIIα. Methods: A retrospective analysis was therefore performed on 103 consecutive patients with either limited stage (LS) or extensive stage (ES) SCLC. Total RNA was extracted from microdissected sections of 103 formalin-fixed, paraffin embedded pre-treatment biopsies of SCLC patients. Relative quantifi…

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