volume 2, issue 8, PS451 2007
DOI: 10.1097/01.jto.0000283381.78585.f2
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Abstract: Results:We found 10 RCTs including 1575 patients. Longer durations of chemotherapy prolonged PFS (HR 0.83, 95% CI 0.75 to 0.93, p=0.0007) but not OS (HR 0.96, 95%CI 0.87 to 1.05, p=0.3). The results were comparable among the different trials, designs and drugs (heterogeneity p>0.3) and were unaffected by excluding the 3 trials of lowest quality. AE were more frequent with longer durations of chemotherapy. QL was assessed in 5 trials with variable results. Conclusions: Continuing chemotherapy for more than 3 or…

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