PD-L1+ regulatory B cells act as a T cell suppressor in a PD-L1-dependent manner in melanoma patients with bone metastasis

Wu, Hao; Xia, Liming; Jia, Dong-Dong; Zou, Hanhui; Gu, Jin; Qian, Wenkang; Xu, Haichao; Li, Tao

doi:10.1016/j.molimm.2020.01.008

Cited by 42 publications

(35 citation statements)

References 38 publications

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“…Furthermore, Bregs harvested from the glioblastoma tissue of patients suppressed CD8 + T cell proliferation and the acquisition of an effector phenotype (82). Moreover, PD-L1 + Bregs from stage II/III/IV melanoma patients impaired IFN-g production by CD8 + T cells in a PD-L1-dependent manner in a co-culture system (41). Another study by Xiao et al demonstrated a novel protumorigenic PD-1 hi Breg subset in human HCC (40).…”

Section: Suppression Of Effector T Cell Responsesmentioning

confidence: 99%

Phenotypes, Functions, and Clinical Relevance of Regulatory B Cells in Cancer

Shang

Zha²,

Sun

2020

Front. Immunol.

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In immune system, B cells are classically positive modulators that regulate inflammation and immune responses. Regulatory B cells (Bregs) are a subset of B cells which play crucial roles in various conditions, including infection, allergies, autoimmune diseases, transplantation, and tumors. Until now, unequivocal surface markers for Bregs still lack consensus, although numerous Breg subsets have been identified. Generally, Bregs exert their immunoregulatory functions mainly through cytokine secretion and intercellular contact. In the tumor microenvironment, Bregs suppress effector T cells, induce regulatory T cells and target other tumor-infiltrating immune cells, such as myeloidderived suppressor cells, natural killer cells and macrophages, to hamper anti-tumor immunity. Meanwhile, the cross-regulations between Bregs and tumor cells often result in tumor escape from immunosurveillance. In addition, accumulating evidence suggests that Bregs are closely associated with many clinicopathological factors of cancer patients and might be potential biomarkers for accessing patient survival. Thus, Bregs are potential therapeutic targets for future immunotherapy in cancer patients. In this review, we will discuss the phenotypes, functions, and clinical relevance of Bregs in cancer.

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Section: Suppression Of Effector T Cell Responsesmentioning

confidence: 99%

Phenotypes, Functions, and Clinical Relevance of Regulatory B Cells in Cancer

Shang

Zha²,

Sun

2020

Front. Immunol.

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“…Cell migration due to chemotaxis can also be observed in processes related to tumor development, as it has been demonstrated with T-cells serving as the basis for the recently developed immune therapies [66]. In this sense, the PD-1/PD-L1 axis blockage is a promising therapeutic tool that is being successfully used in several types of malignant tumors, including kidney [67], breast [68], lung [69] and bladder [70] cancers, as well as malignant melanoma [71]. Chemotaxis can be associated to the so-called haptotaxis, which refers to the directional motility induced by a gradient of cell adhesion [34] and differs from chemotaxis in the nature of the chemoattractant molecule.…”

Section: External Stimuli Migration and Cancermentioning

confidence: 99%

Cell Motility and Cancer

Fuente

López

2020

Cancers

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Cell migration is an essential systemic behavior, tightly regulated, of all living cells endowed with directional motility that is involved in the major developmental stages of all complex organisms such as morphogenesis, embryogenesis, organogenesis, adult tissue remodeling, wound healing, immunological cell activities, angiogenesis, tissue repair, cell differentiation, tissue regeneration as well as in a myriad of pathological conditions. However, how cells efficiently regulate their locomotion movements is still unclear. Since migration is also a crucial issue in cancer development, the goal of this narrative is to show the connection between basic findings in cell locomotion of unicellular eukaryotic organisms and the regulatory mechanisms of cell migration necessary for tumor invasion and metastases. More specifically, the review focuses on three main issues, (i) the regulation of the locomotion system in unicellular eukaryotic organisms and human cells, (ii) how the nucleus does not significantly affect the migratory trajectories of cells in two-dimension (2D) surfaces and (iii) the conditioned behavior detected in single cells as a primitive form of learning and adaptation to different contexts during cell migration. New findings in the control of cell motility both in unicellular organisms and mammalian cells open up a new framework in the understanding of the complex processes involved in systemic cellular locomotion and adaptation of a wide spectrum of diseases with high impact in the society such as cancer.

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“…For PD-L1 expression, B cells from the healthy control group showed little expression of PD-L1, B-cells from patients with stage I and II melanoma showed detectable low PD-L1, and naive B cells from stage III and IV showed moderate PD-L1. Moreover, compared with primary tumors, PD-L1 + B cells were upregulated in advanced melanomas and enriched in metastases 15 . Overall, high expression of PD-L1 on B cells is generally considered to be one of the characteristics of immunoregulatory functions that inhibit T cell proliferation and promote tumor progression in many types of tumors 16 .…”

Section: Immune Cells With High Expression Of Pd-1 or Pd-l1 Help Predmentioning

confidence: 98%

“…The latest research in glioblastomas (GBMs) showed PD-L1 overexpression on GBM-associated regulatory B cells (Bregs), which has immunosuppressive activity against activated CD8 + T cells. Production of the immunosuppressive cytokine transforming growth factor-β (TGF-β) and IL-10 38 in melanomas and PD-L1 + B cells can suppress T cell immune responses in a PD-L1-dependent manner 15 .…”

Section: Effects Of Immune Cells With High Expression Of Pd-1 or Pd-lmentioning

confidence: 99%