volume 190, issue 12, P6277-6286 2013
DOI: 10.4049/jimmunol.1300582
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Sohyun Jeon, Anthony J. St. Leger, Thomas L. Cherpes, Brian S. Sheridan, Robert L. Hendricks

Abstract: Herpes simplex virus type 1 (HSV)-specific CD8+ T cells provide immunosurveillance of trigeminal ganglion (TG) neurons that harbor latent HSV-1. In C57BL/6 mice the TG-resident CD8+ T cells are HSV-specific and maintain a 1:1 ratio of cells recognizing an immunodominant epitope on viral glycoprotein B (gB498–505-Tet+) and cells reactive to subdominant epitopes (gB-Tet−). The gB-Tet− CD8+ T cells maintain their frequency in TG by balancing a higher rate of proliferation with a correspondingly higher rate of ap…

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