volume 7, issue S4, PS530-S537 2018
DOI: 10.21037/tcr.2018.04.04
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Priya Veluswamy, Dunja Bruder

Abstract: T cell exhaustion is a well-known mechanism involved in escape of degenerated cells or certain pathogens from CD8 + T cell-mediated immune surveillance, ultimately resulting in tumor development and chronic infections, respectively. Next to activated T cells, exhausted CD8 + T cells typically express high levels of the programmed cell death-1 (PD-1) receptor. While interaction of PD-1 with its ligand programmed death-ligand 1 (PD-L1) on hemotopoietic and non-hemotopoietic cells is important for the re-establis…

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