PD-0184: Protective effect of leuprorelin on radiation-induced intestinal toxicity

Volumetric image-guided highly conformal radiotherapy of the prostate bed: Toxicity analysis

“…26,27 Analyzing our toxicity data in correlation with patients' clinical variables, the log-rank test evidenced a protective effect of hormonal therapy on the intestinal tissue (weak correlation), as reported in other studies 28,29 and demonstrated in animal models. 30 We found that antihypertensive medication increases the risk of acute GI toxicity, whereas it seems to have a protective effect in the series by Fellin et al 31 Finally, the use of anticoagulants or antiaggregants is weakly associated to late GI toxicity, as reported by Choe et al 29 and Takeda et al 32 Our Cox proportional hazards regression confirms the relation between dose-volume parameters (maximal dose to the rectum, and bladder V 65 ) and toxicity. Hence, new treatment strategies addressed to reduce the irradiation of normal tissues might allow dose escalation and hypofractionation, 20 which are becoming common in the post-prostatectomy setting.…”

A PPAR‐gamma agonist protects from radiation‐induced intestinal toxicity

“…In this study, we evaluated the radioprotective properties of RGZ (5 mg/kg/day started 24 hours before RT) in normal bowel tissue in a murine model of intestinal injury induced by 12-Gy TBI, as previously described. 30,31 Histological analysis revealed that IR caused noticeable intestinal damage, with villi shortening, submucosal thickening, crypt necrotic changes, oedema and inflammatory infiltrate, and increased numbers of TUNEL-positive (apoptotic) cells. RGZ produced histological improvement of tissue structure, with normalization of villi and crypts and oedema and reduction of inflammatory infiltrate and apoptotic cell death.…”

Tomotherapy-based moderate hypofractionation for localized prostate cancer: a mono-institutional analysis

“…Recently, Palumbo et al [20] reported that statins were an independent factor associated with the reduction of acute GI toxicity in 195 patients treated with IMRT for localized PCa. The protective effect of ADT on the intestinal tissue, which has been demonstrated in animal models [21] as well as in clinical studies [22][23][24], could depend on the reduction of radiation-induced cytokines and pro-inflammatory molecules (i.e., IL-6, NFkB, TGFβ) [21] within the irradiated rectal wall in patients under androgen deprivation. We identified anticoagulants and antiaggregants as clinical variables associated with acute GU toxicity, but we have to consider that anticoagulant therapy itself is a risk factor for urinary complaints and hematuria.…”