Biochemical Pharmacology volume 76, issue 12, P1653-1668 2008 DOI: 10.1016/j.bcp.2008.09.003 View full text
Soo In Bae, Ran Zhao, Robert M. Snapka

Abstract: AbstractStructurally diverse chemotherapeutic and chemopreventive drugs, including camptothecin, doxorubicin, sanguinarine, and others, were found to cause covalent crosslinking of proliferating cell nuclear antigen (PCNA) trimers in mammalian cells exposed to fluorescent light. This PCNA damage was caused by both nuclear and cytoplasmically localizing drugs. For some drugs, the PCNA crosslinking was evident even with very brief exposures to laboratory room lighting. In the absence of drugs, there was no dete…

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