PCH-2 regulates Caenorhabditis elegans lifespan

Qian, Hong; Xu, Xiangru; Niklason, Laura E.

doi:10.18632/aging.100713

Cited by 16 publications

(22 citation statements)

References 29 publications

(30 reference statements)

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“…This microscopic model system is preferred due to its short life cycle and transparent cuticle, which enables to monitor the physiological changes through a microscope. Moreover, it facilitates to study the regulation of single gene, which can make a significant change in lifespan or any other physiological activity, through RNAi-mediated approach (Qian et al 2015). …”

Section: Introductionmentioning

confidence: 99%

Ultraviolet-A triggers photoaging in model nematode Caenorhabditis elegans in a DAF-16 dependent pathway

Prasanth

Santoshram

Bhaskar

et al. 2016

AGE

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Ultraviolet radiations (UV) are the primary causative agent for skin aging (photoaging) and cancer, especially UV-A. The mode of action and the molecular mechanism behind the damages caused by UV-A is not well studied, in vivo. The current study was employed to investigate the impact of UV-A exposure using the model organism, Caenorhabditis elegans. Analysis of lifespan, healthspan, and other cognitive behaviors were done which was supported by the molecular mechanism.

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Section: Introductionmentioning

confidence: 99%

Ultraviolet-A triggers photoaging in model nematode Caenorhabditis elegans in a DAF-16 dependent pathway

Prasanth

Santoshram

Bhaskar

et al. 2016

AGE

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“…4E-BP is a downstream effector of the TOR signaling pathway that negatively regulates translation (Katewa and Kapahi, 2011). While heart-specific rpd3 reduction increases the levels of 4E-BP mRNA in the whole body of 2 days old flies, we found that flies carrying rpd3 mutations have decreased levels of 4E-BP mRNA in the heads and thoraces at 20 and 40 days of age (Frankel et al, 2015). Therefore, it is most likely that there are complex interactions between Rpd3, 4E-BP, and DR (Frankel et al, 2015).…”

Section: Effects Of Rpd3 On Longevitymentioning

confidence: 67%

“…When longevity studies were done on diets with varying caloric content, rpd3 -mediated longevity was additive with extension mediated by some diet levels, suggesting that the interplay between Rpd3 and DR is more complex then previously thought (Frankel et al, 2015). We also showed potential interaction between rpd3 -mediated longevity and the protein synthesis regulator 4E-BP, based on a reduction of longevity effects in flies mutant for both rpd3 and 4E-BP compared to the longevity of flies only mutant for rpd3 .…”

Section: Effects Of Rpd3 On Longevitymentioning

confidence: 89%

“…Genetic manipulations that decrease yeast and fly rpd3 levels extend longevity (Kim et al, 1999; Rogina et al, 2002; Rogina and Helfand, 2004; Pallos et al, 2008; Cao et al, 2014; Kopp et al, 2015; Frankel et al, 2015). On the other hand, overexpression of Sir2 genetically or pharmacologically in yeast, worm, fly, and mice extends healthspan and/or longevity (Kaeberlain et al, 1999; Imai et al, 2000; Tissenbaum and Guarente, 2001; Rogina and Helfand, 2004; Wood et al, 2004; Frankel et al, 2011; Whitaker et al, 2013, Banerjee et al, 2012; Kanfi et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

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The effects of Rpd3 on fly metabolism, health, and longevity

Woods

Rogina

2016

Experimental Gerontology

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The epigenetic regulation of DNA structure and function is essential for changes in gene expression involved in development, growth, and maintenance of cellular function. Epigenetic changes include histone modifications such as methylation, acetylation, ubiquitination, and phosphorylation. Histone deacetylase (HDAC) proteins have a major role in epigenetic regulation of chromatin structure. HDACs are enzymes that catalyze the removal of acetyl groups from lysine residues within histones, as well as a range of other proteins including transcriptional factors. HDACs are highly conserved proteins divided into two families and based on sequence similarity in four classes. Here we will discuss the roles of Rpd3 in physiology and longevity with emphasis on its role in flies. Rpd3, the Drosophila HDAC1 homologue, is a class I lysine deacetylase and a member of a large family of HDAC proteins. Rpd3 has multiple functions including control of proliferation, development, metabolism, and aging. Pharmacological and dietary HDAC inhibitors have been used as therapeutics in psychiatry, cancer, and neurology.

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“…Aside from manipulating the immune system, recent studies using heterochronic parabiosis (surgical connection of the circulatory systems of two mice of different ages) has implicated several members of the transforming growth factor β (TGFβ) family in age-related disease (reviewed by Conboy et al, 2015). TGFβ family members are involved in regulation of a variety of developmental and regenerative processes in many tissues.…”

Section: Repurposing Drugs To Combat Ageingmentioning

confidence: 99%

Therapeutic Manipulation of Ageing: Repurposing Old Dogs and Discovering New Tricks

Mallikarjun

Swift

2016

EBioMedicine

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Ageing is a leading risk factor for many debilitating diseases. While age-related diseases have been the subject of over a century of intense investigation, until recently, physiological ageing was considered unavoidable. Pharmacological and genetic studies have since shown that ageing is a malleable process and that its abrogation can prevent its associated diseases. This review summarises a sample of the most promising efforts to deliver the products of ageing research to the clinic. Current efforts include the use of clinically approved drugs that have since been repurposed, as well as the development of novel therapeutics, to target ageing. Furthermore, ongoing research has sought reliable biomarkers of ageing that will accelerate the development of such therapeutics. Development of these technologies will improve quality of late-life and help relieve the enormous stress placed on state healthcare systems by a rapidly ageing global population. Thus, for both medical and socioeconomic reasons, it is imperative that ageing is made to yield to intervention.

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PCH-2 regulates Caenorhabditis elegans lifespan

Cited by 16 publications

References 29 publications

Ultraviolet-A triggers photoaging in model nematode Caenorhabditis elegans in a DAF-16 dependent pathway

Ultraviolet-A triggers photoaging in model nematode Caenorhabditis elegans in a DAF-16 dependent pathway

The effects of Rpd3 on fly metabolism, health, and longevity

Therapeutic Manipulation of Ageing: Repurposing Old Dogs and Discovering New Tricks

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