PCB and other organochlorine compounds in blood of women with or without miscarriage: A hypothesis of correlation

Leoni, Valerio; Fabiani, L; Marinelli, Giuseppe; Puccetti, G; Tarsitani, G; Carolis, Aurora De; Vescia, N; Morini, A; Aleandri, Vincenzo; Pozzi, V; Cappa, F; Barbati, D.

doi:10.1016/0147-6513(89)90002-x

Cited by 75 publications

(39 citation statements)

References 24 publications

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“…Blood PCB levels among women with miscarriage were found to be higher than in women with normal deliveries in one study (72), but the level of many potentially confounding factors were related to PCB levels and the analysis included no adjustment for these.…”

Section: Data On Human Health Effectsmentioning

confidence: 99%

See 1 more Smart Citation

The Human Health Effects of DDT (Dichlorodiphenyltrichloroethane) and PCBS (Polychlorinated Biphenyls) and an Overview of Organochlorines in Public Health

Longnecker

Rogan

Lucier

1997

Annu. Rev. Public Health

416

205

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Organochlorines are a diverse group of persistent synthetic compounds, some of which are detectable in nearly everyone. Many organochlorines are endocrine disruptors or carcinogens in experimental assays. p,p -DDE (dichlorodiphenyldichloroethene) and PCBs (polychlorinated biphenyls) comprise the bulk of organochlorine residues in human tissues. We reviewed relevant human data cited in the 1991-1995 Medline database and elsewhere. High-level exposure to selected organochlorines appears to cause abnormalities of liver function, skin (chloracne), and the nervous system. Of more general interest, however, is evidence suggesting insidious effects of background exposure. Of particular concern is the finding of neonatal hypotonia or hyporeflexia in relation to PCB exposure. The epidemiologic data reviewed, considered in isolation, provide no convincing evidence that organochlorines cause a large excess number of cancers. A recent risk assessment

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Section: Data On Human Health Effectsmentioning

confidence: 99%

“…The two most statistically powerful studies of this issue (72,84) were case-control studies of maternal blood DDT (primarily p,p -DDE) levels in relation to spontaneous abortion. In neither study were case-control differences evident.…”

Section: Data On Human Health Effectsmentioning

confidence: 99%

The Human Health Effects of DDT (Dichlorodiphenyltrichloroethane) and PCBS (Polychlorinated Biphenyls) and an Overview of Organochlorines in Public Health

Longnecker

Rogan

Lucier

1997

Annu. Rev. Public Health

416

205

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“…Their affected length of menstrual cycle [13] or pregnancy [14,15] as well as PCBs even increased the frequency of miscarriages in women [16] or monkeys [17]. Next, it was stated that the PCBs treatment has been associated with the increase of frequency or force of myometrial strips contractions in vitro in rats [18] or cows [19], respectively.…”

Section: Introductionmentioning

confidence: 99%

“…16. Leoni V, Fabiani L, Marinelli G, Puccetti G, Tarsitani GF, et al (1989) PCB and other organochlorine copounds in blood of women with or without miscarriage: a hypothesis of correlation. Ecotox Environ Safety 17: 1-17.…”

mentioning

confidence: 99%

The Preliminary Study About the Involvement of Relaxine in Adverse Effect of Polychlorinated Biphenyls on Bovine Myometrial Contractions

Wróbel¹

2017

J Clin Mol Endocrinol

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Polychlorinated biphenyls (PCBs) are a group of synthetic xenobiotics, which were used in lots of industrial applications. Two individual congers (PCB 153 and PCB 77) belong to the most prominent environmental contaminations among PCBs, but they have opposite type of configuration and therefore they can exert a different way of action. Since PCBs increased the force of myometrial contractions, in this work, their effect on myometrial sensitivity on inhibitor of myometrial contractions (relaxine, RLX) was studied.Bovine myometrial cells and strips, and luteal cell at 4-8 month of pregnancy, were obtained accidentally in commercial abattoir. They were treated by PCB 153 and PCB 77 and mRNA expression of RLX receptor in myometrial cells and contractions of myometrial strips as well as the secretion of progesterone (P4) and oxytocin (OT) from luteal cells, were measured under their effect.Both studied congeners decreased (P<0.05) the mRNA expression of RLX receptor in myometrium. Admittedly, both PCB 77 and 153 increased (P<0.05) the basal force of contractions, while RLX showed any effect on myometrial contractions. Studied PCBs increased also (P<0.05) secretion of P4 and OT from luteal cells.It is suggested that PCBs can decreased the sensitivity of myometrium on RLX but their direct effect on RLX function have to be further investigated. Keywords: Endocrine Disruption; Pregnancy; Uterus IntroductionPolychlorinated biphenyls (PCBs) are a group of synthetic, chlorinated aryl hydrocarbons, which were extensively used in lots of industrial applications, mainly in transformers, capacitors or as hydraulic fluids, heat exchange liquids as well as plasticizers and others [1]. Because of different degree of chlorination, there are possible up to 209 congeners of PCBs. Among them, 3,3 ' ,4,4 ' -tetrachlorobiphenyl (PCB 77) is one of the most abundant PCB congeners in human milk. This congener is a non-ortho chlorine substituted with coplanar configuration and appear to exert its toxic effects via interacting with the cytosolic aryl hydrocarbon receptor (Ahr). Hence is recognized also as dioxin-like PCBs [2]. Since PCB 77 can affect the cell also through estrogen [3] and glucocorticoid receptors [4], it is recognized as a significant environmental pollutant and endocrine disruptor [3] with a wide spectrum of way of action. Admittedly 2,2',4,4', 5,5'-hexachlorobiphenyl PCB 153 is also one of the most prominent environmental contaminants, but oppositely to PCB 77 is classified as di-ortho, non-coplanar, non-dioxin congener of PCBs [5] and is known to have rather estrogenic properties [6]. Even though PCBs production and use were banned in USA and Europe more than three decades ago, they are still measured in environment [7]. Due to their lipophilic nature and resistance for biodegradation, PCBs have been bio-accumulated in animal tissues [8], also in domestic animals [9,10]. Therefore PCBs have been also measured in food samples [11] and they can be mentioned as a serious health risk.Since PCBs accumulation in preg...

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“…Exposure to persistent organochlorine compounds (eg, polychlorinated biphenyls) and dioxins, has been found to affect reproductive outcomes in humans, for example, menstrual cycle length (1), occurrence of spontaneous abortions (2,3), missed abortions (4), and time to pregnancy (5). In animal studies, the primary effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on female reproduction appear to be decreased fertility and the inability to maintain a pregnancy for the full gestational period (6).…”

mentioning

confidence: 99%

Female fertility in relation to the consumption of fish contaminated with persistent organochlorine compounds

Axmon¹,

Rylander²,

Strömberg³

et al. 2002

Scand J Work Environ Health

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PCB and other organochlorine compounds in blood of women with or without miscarriage: A hypothesis of correlation

Cited by 75 publications

References 24 publications

The Human Health Effects of DDT (Dichlorodiphenyltrichloroethane) and PCBS (Polychlorinated Biphenyls) and an Overview of Organochlorines in Public Health

The Human Health Effects of DDT (Dichlorodiphenyltrichloroethane) and PCBS (Polychlorinated Biphenyls) and an Overview of Organochlorines in Public Health

The Preliminary Study About the Involvement of Relaxine in Adverse Effect of Polychlorinated Biphenyls on Bovine Myometrial Contractions

Female fertility in relation to the consumption of fish contaminated with persistent organochlorine compounds

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