Patterns of levels of biological metals in CSF differ among neurodegenerative diseases

Hozumi, Isao; Hasegawa, Tatsuya; Honda, Akira; Ozawa, Kazuhiro; Hayashi, Yuichi; Hashimoto, Kazunori; Yamada, Megumi; Koumura, Akihiro; Sakurai, Takeo; Kimura, Akio; Tanaka, Yuji; Satoh, Masahiko; Ishii, Takashi

doi:10.1016/j.jns.2011.01.003

Cited by 217 publications

(153 citation statements)

References 24 publications

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“…Thus, physiological Mn concentrations in CSF are comparable with serum concentrations, ranging from 1.0 Ϯ 0.5 g/liter in nonexposed patients to severalfold higher levels in exposed patients (56,57). This fact might have contributed to the assumption frequently discussed in literature that Mn enters the brain at normal physiological plasma concentrations across the capillary endothelium, whereas at high plasma concentrations, Mn transfer across the CP appears to predominate (3,43).…”

Section: Discussionmentioning

confidence: 67%

Impact of Manganese on and Transfer across Blood-Brain and Blood-Cerebrospinal Fluid Barrier in Vitro

Bornhorst

Wehe

Hüwel

et al. 2012

Journal of Biological Chemistry

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Background: Modes of neurotoxic action after Mn overexposure are not fully understood. Results:The blood-CSF barrier showed higher Mn sensitivity and active Mn transport properties. Conclusion:The blood-CSF barrier might be the major route for Mn into the brain. Significance: Deeper insight in the impact of Mn on and its transfer across brain barrier systems might help to prevent irreversible neurological damage.

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Section: Discussionmentioning

confidence: 67%

Impact of Manganese on and Transfer across Blood-Brain and Blood-Cerebrospinal Fluid Barrier in Vitro

Bornhorst

Wehe

Hüwel

et al. 2012

Journal of Biological Chemistry

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“…Scientific evidence has shown metals presence in the cerebrospinal fluid, suggesting fascinating perspectives for future research. In particular, Hozumi et al have described different patterns of metals concentrations specific for different types of neurodegenerative diseases [77]. Some metals investigated as implicated in ALS are correlated to the mercury (Hg) and cadmium.…”

Section: Etiology Of Als As Well As the Onset Mechanismsmentioning

confidence: 99%

Risk agents related to work and amyotrophic lateral sclerosis: An occupational medicine focus

Garzillo

Miraglia

Pedata

et al. 2015

Int J Occup Med Environ Health

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Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by progressive muscular paralysis reflecting degeneration of motor neurons. In recent years, in addition to several studies about genetic mechanisms leading to motor neurons damage, various epigenetic theories have been developed, involving the study of the patients' work and lifestyle. The work aims at focusing the role of occupational exposure related to ALS by literature data analysis. Articles, selected on the basis of keywords, year of publication and topics, are related to occupational exposure, suggesting an impact on ALS onset. The literature review shows that there are still a lot of biases in the studies design, which actually do not allow to draw unequivocal conclusions.

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“…Abnormal levels of various Se species have been found in cerebrospinal fluid of ALS patients [36] and circulating levels of Se, usually bound to serum albumin, could reflect the Se levels present in the Central Nervous System. Finally, we were not able to find a correlation between Fe levels and ALS in the group of patients considered in this study, although several reports previously assessed this relationship [14,[37][38][39].…”

Section: Pbmentioning

confidence: 58%

Serum metal evaluation in a small cohort of Amyotrophic Lateral Sclerosis patients reveals high levels of thiophylic species

Benedetti¹,

Lucchini²,

Marocchi³

et al. 2016

Peptidomics

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Amyotrophic Lateral Sclerosis (ALS) has often been associated with improper/altered metal metabolism. Analysis of thiophylic metals in serum from a small and geographically restricted cohort of ALS patients indicates contents of Pb and Ni much higher in patients than in controls (Ni, 5-fold; Pb, 2-fold). Se levels are also higher in the patients’ group, which has instead lower As levels than controls. Thiophylic metals may impair biogenesis of FeS clusters or substitute for iron, even in folded proteins; Se may non-functionally replace S. Thus, improper assembly/ function of FeS proteins could represent another possible issue to be considered in ALS pathogenesis.

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Patterns of levels of biological metals in CSF differ among neurodegenerative diseases

Cited by 217 publications

References 24 publications

Impact of Manganese on and Transfer across Blood-Brain and Blood-Cerebrospinal Fluid Barrier in Vitro

Impact of Manganese on and Transfer across Blood-Brain and Blood-Cerebrospinal Fluid Barrier in Vitro

Risk agents related to work and amyotrophic lateral sclerosis: An occupational medicine focus

Serum metal evaluation in a small cohort of Amyotrophic Lateral Sclerosis patients reveals high levels of thiophylic species

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