Patterns of first-line targeted therapy utilization and adherence among older adults diagnosed with metastatic renal cell carcinoma

Hicks, Blánaid; Chun, Danielle S.; Hinton, Sharon Peacock; Hsu, Christine D.; Tan, Hung‐Jui; Lund, Jennifer L.

doi:10.1016/j.jgo.2021.11.006

Cited by 1 publication

(3 citation statements)

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“…The incidence of RCC has increased worldwide at an annual rate of 1.5-5.9% and accounts for about 3% of all human cancers. Almost 25-30% patients with RCC have metastatic disease at the time of diagnosis and survival outcomes for these patients are suboptimal, and Therefore, finding new effective treatment methods for RCC provides new theoretical basis for treatment of tumors, and has important clinical significance for improving the survival rate and cure rate of cancer patients (9)(10)(11)(12). The miRNA is a class of endogenous single-stranded small RNA that regulate life activities.…”

Section: Discussionmentioning

confidence: 99%

“…Almost 25–30% patients with RCC have metastatic disease at the time of diagnosis and survival outcomes for these patients are suboptimal, and the 5-year progression-free survival rate of only 30% ( 1 - 4 ). Therefore, finding new effective treatment methods for RCC provides new theoretical basis for treatment of tumors, and has important clinical significance for improving the survival rate and cure rate of cancer patients ( 9 - 12 ).…”

Section: Discussionmentioning

confidence: 99%

“…However, postoperative recurrence and metastasis rates of RCC are high, and 5-year overall survival rates are about 20% ( 8 ). Currently, RCC, which shows little response to chemoradiotherapy, is undergoing rapid development with the application of targeted therapy ( 9 ). Arsenic trioxide (As 2 O 3 ) is a Food and Drug Authority (FDA)-approved drug used to treat acute promyelocytic leukemia (APL).…”

Section: Introductionmentioning

confidence: 99%

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MiRNA-148a inhibits cell growth and drug resistance by regulating WNT10a expression in renal cell carcinoma

Chen¹,

Liu²,

Li³

et al. 2022

Transl Androl Urol

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Background: We aimed to explore miR-148a exerts a tumor suppressor effect and arsenic trioxide (As 2 O 3 ) sensitivity on renal cell carcinoma (RCC).Methods: We performed polymerase chain reaction (PCR) on 42 pairs of tumor and paracancerous samples collected from RCC patients to investigate the miR-148a expression; meanwhile, we analyzed the interplay between clinical indicators and miR-148a expression of RCC. Then, the influence of miR-148a overexpression on the functions of RCC cells were analyze using transwell migration assay, Cell Counting Kit-8 (CCK-8), and cell wound healing assay. Furthermore, the ability of miR-148a to sensitize Caki-1 cells treated with As 2 O 3 were detected using flow cytometry. Finally, the relevant mechanism of miR-148a on the downstream gene Wnt family member 10A (WNT10a) was explored by cell reverse method.Results: The results from RCC patients indicated a significantly lower miR-148a level than adjacent tissues. The low miR-148a expression increased prevalence of distant metastasis and decreased survival rate compared to those with high expression in patients. In the RCC cell lines, the proliferation and metastasis ability of the miR-148a mimic group was remarkably lower than the miR-NC group. At the same time, it was verified that WNT10a was remarkably higher cell lines and RCC tissues; and negatively related to miR-148a expression. In addition, miR-148a mimics were found to remarkably reduce the protein expression of WNT10a. In the cell reverse experiment, overexpression of WNT10a was confirmed to offset the miR-148a mimics effect on metastasis and proliferation of RCC cells. In addition, an increase in relative apoptosis was detected in As 2 O 3 treated with/without miR-148a mimics for 48 hours, and apoptosis was significantly reduced after transfection with WNT10a in the Caki-1 cell line and significantly reduced after combined treatment. Conclusions:The study revealed that miR-148a is associated with distant metastases and leads to poor prognosis in RCC patients. Moreover, miR-148a inhibit the malignant progression and increase the sensitivity of RCC cells to As 2 O 3 by regulating WNT10a.

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Section: Discussionmentioning

confidence: 99%