Patterns of depressed mood across the menopausal transition: approaches to studying patterns in longitudinal data

Woods, NancyFugate; Mariella, Anne; Mitchell, EllenSullivan

doi:10.1080/j.1600-0412.2002.810708.x

Cited by 10 publications

(11 citation statements)

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“…5 Other studies report an association between a history of postpartum depression and increased risk of depression in the perimenopausal stage. 9, 26 …”

Section: Discussionmentioning

confidence: 99%

Depressive symptoms are increased in the early perimenopausal stage in ethnically diverse human immunodeficiency virus–infected and human immunodeficiency virus–uninfected women

Maki

Rubin²,

Cohen

et al. 2012

Menopause

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Objective The risk of clinically significant depressive symptoms increases during the perimenopause. With highly active antiretroviral treatment (HAART), more HIV-infected women survive to transition through the menopause. In a cross-sectional analysis, we evaluated the association of menopausal stage and vasomotor symptoms with depressive symptoms in an ethnically diverse, cohort of women with a high prevalence of HIV. Methods Participants included 835 HIV-infected women and 335 HIV-uninfected controls from the Women’s Interagency HIV Study (WIHS; 63% African-American). The Center for Epidemiological Studies Depression (CES-D) scale was used to screen for elevated depressive symptoms. Menopausal stages were defined according to standard definitions. Logistic regression analysis was used to identify predictors of elevated depressive symptoms. Results Compared to premenopausal women, early perimenopausal (OR 1.74, 95%CI 1.17–2.60), but not late perimenopausal or postmenopausal women were more likely to show elevated depressive symptoms in adjusted analyses. The odds were similar in HIV-infected and HIV-uninfected women. Persistent vasomotor symptoms also predicted elevated depressive symptoms in HIV-infected and uninfected women (OR 1.45, 95%CI 1.02–2.06). In HIV-infected women, menopausal stage interacted with antiretroviral use (p=0.02); the likelihood of elevated depressive symptoms in early perimenopause compared with premenopause was especially high in HAART-untreated women (OR 3.87, 95%CI 1.57–9.55). Conclusions In HIV+ and HIV− women, the odds of elevated depressive symptoms were significantly higher during the early perimenopause. Elevated depressive symptoms were associated with nonadherence to HAART, underscoring the importance of screening and treating depressive symptoms in HIV+ women who have experienced a change in the regularity of their menstrual cycles.

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“…5 Other studies report an association between a history of postpartum depression and increased risk of depression in the perimenopausal stage. 9, 26 …”

Section: Discussionmentioning

confidence: 99%

Depressive symptoms are increased in the early perimenopausal stage in ethnically diverse human immunodeficiency virus–infected and human immunodeficiency virus–uninfected women

Maki

Rubin²,

Cohen

et al. 2012

Menopause

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“…Where reproductive stage measures are available, the prevalence of depressed mood symptoms (e.g., feeling sad or blue) ranged from 19% to 29%. For women in the early or late menopausal transition stages, prevalence estimates ranged from 28% to 29%; for those who had completed menopause, the prevalence of depressed mood symptoms ranged from 24.5% to 29% (late reproductive) to 23% to 28% (late MT) to 23% to 34% (postmenopause) 4,[21][22][23][24][25][26][27] ( Table 2 4 ,5,19,22-24,28 -32 ).…”

Section: Depressed Moodmentioning

confidence: 99%

“…The Seattle Midlife Women's Health Study investigators identified clusters of women based on their CES-D scores (level and trajectory) over a 10-year period. 25 The most prevalent cluster included women who had nondepressed scores (4 to 7) and low-level scores (8 to 10). Other clusters included women with moderate-level scores (10 to 19) that remained constant, improved, or worsened over time and a cluster of women with high scores (most Ͼ24) that remained constant over time.…”

Section: Depressed Moodmentioning

confidence: 99%

Symptoms during the perimenopause: prevalence, severity, trajectory, and significance in women’s lives

Woods

Mitchell

2005

The American Journal of Medicine

379

209

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This article examines published evidence from longitudinal studies of the menopausal transition that address the following questions: (1) Which symptoms do women report during the perimenopause, and how prevalent are these symptoms as women traverse the menopausal transition? (2) How severe are symptoms and for how long do they persist? (3) To what do women attribute their symptoms, and do their attributions match findings from epidemiologic studies of community-based populations? (4) How significant are these symptoms in women's lives? Data from published longitudinal studies were examined for evidence bearing on each of these questions. Only vasomotor symptoms, vaginal dryness, and sleep disturbance symptoms varied in prevalence significantly across menopausal transition stages and postmenopause in >1 population studied. A minority of women report severe symptoms. Given the limited follow-up data available, it is unclear how long symptoms persist after menopause. Women attribute their symptoms to a variety of biologic and psychosocial factors, and their attributions correspond well to those correlates identified in epidemiologic studies of community-based populations. The significance of symptoms for women's lives remains uncertain. The impact of symptoms during the perimenopause on well-being, role performance, adaptation to demands of daily living, and quality of life warrants additional study. The appraisal of the consequences of perimenopausal symptoms by women from different ethnic groups will be enhanced significantly as a result of the Study of Women's Health Across the Nation (SWAN) and other studies in progress.

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“…Specific topics addressed by the SMWHS included women's perceptions and expectations of menopause, mood and depression, memory, menopausal symptoms, hormone therapy, well‐being, stress, and menopausal stages, for example, Refs. 22 and 23. Endocrine data have been assessed in relation to factors, such as menopausal symptoms and stages, and genetic polymorphisms in the estrogen pathway 21,24 .…”

Section: Study Summariesmentioning

confidence: 99%

Longitudinal, epidemiologic studies of female reproductive aging

Ferrell

Sowers

2010

Annals of the New York Academy of Sciences

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Human female reproductive aging consists of multiple processes and interacts with other physiological systems in unique ways. Here we discuss eight recent longitudinal, epidemiologic studies of female reproductive aging that include endocrine data to highlight their contributions to our understanding of these various aging processes and their interactions. Specifically, we review data on ovarian and nonovarian reproductive aging processes and reproductive staging. We consider these data in the context of longitudinal research design and research goals, identify limitations of the studies but also ways in which existing longitudinal data can further our understanding of aging processes, and make recommendations for future studies of female reproductive aging.

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Patterns of depressed mood across the menopausal transition: approaches to studying patterns in longitudinal data

Cited by 10 publications

References 0 publications

Depressive symptoms are increased in the early perimenopausal stage in ethnically diverse human immunodeficiency virus–infected and human immunodeficiency virus–uninfected women

Depressive symptoms are increased in the early perimenopausal stage in ethnically diverse human immunodeficiency virus–infected and human immunodeficiency virus–uninfected women

Symptoms during the perimenopause: prevalence, severity, trajectory, and significance in women’s lives

Longitudinal, epidemiologic studies of female reproductive aging

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