Cancer is the second most common disease after cardiovascular disorders for maximum deaths in the world. The present research was undertaken to study the histopathological spectrum of neoplastic lesions in Rural Tertiary Care Hospital in Maharashtra. This retrospective study was carried out in the Department of Pathology at Shri Vasantrao Naik Government Medical College (VNGMC) Yavatmal, Maharashtra during October 2016 to November 2018. A detail history, diagnosis, primary site, morphology of neoplastic lesions and histopathological examination of all the specimens were done.Out of 3608 specimens examined, 724 cases had neoplastic lesions of which 499 cases were benign and 225 cases were malignant. The most commonly reported malignant tumors were those of oral cavity (47), breast (44), and gastrointestinal tract (22). Most commonly reported benign tumors in females were female genital tract lesions which constituted 170 cases followed by benign breast lesion (126) while in males, out of 123 cases, lipoma was diagnosed in 30 cases, followed by prostate hyperplasia (28) and other soft tissue tumor (28). In both the gender oral malignancies were commonest, while in males’ gastrointestinal tract malignancies and in females’ carcinoma of breast were the most frequent malignancies after oral malignancies. Commonest benign lesions in males were lipoma and while in female lesions of genital tract and breast were common.