volume 9, issue 3, P741-752 2017
DOI: 10.18632/aging.101186
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Amandine Pelletier, Charlotte Bernard, Bixente Dilharreguy, Catherine Helmer, Melanie Le Goff, Sandra Chanraud, Jean-François Dartigues, Michèle Allard, Hélène Amieva, Gwénaëlle Catheline

Abstract: The cerebral substratum of age-related cognitive decline was evaluated in an elderly-cohort followed for 12 years (n=306). Participants, free of dementia, received neuropsychological assessments every two years and an MRI exam at baseline and four years later. Cognitive decline was evaluated on two broadly used tests to detect dementia: the Free and Cued Selective Reminding Test (FCSRT), a verbal episodic memory task, and the Isaacs Set Test (IST), a semantic fluency task. Using voxel-based approach, the relat…

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